ORIGINAL RESEARCH

Assessment of diastolic function in patients with chest pain and angiographically normal coronary arteries using ECG-gated spect

Khachirova EA1, Samoylenko LE2, Shevchenko OP1
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Russian Medical Academy of Postgraduate Education, Moscow, Russia

Correspondence should be addressed: Elvira A. Khachirova
Ostrovityanova 1, Moscow, 117997; ur.liam@90kihcle

About paper

Acknowledgements: the authors wish to thank Viktor K. Sychev for kindly allowing them to use the equipment of the Laboratory for Radioisotopes.

Author contribution: Khachirova EA recruited patients for the study, prepared the necessary documentation, participated in conducting the cardiac stress test and SPECT/CT, and processed the obtained data; Samoylenko LE controlled the course of the study and double-checked the obtained results; Shevchenko OP made sure inclusion and exclusion criteria were met.

Received: 2018-09-17 Accepted: 2018-11-11 Published online: 2019-02-23
|
  1. Hogg K, Swedberg K, McMurray J. Heart Failure with preserved left ventricular systolic function. Epidemiology, Clinical Characteristics, and Prognosis. J Am Coll Cardiol. 2004; 43 (3): 317–27.
  2. Fomin IV, Belenkov JuN, Mareev Vju, et al. Rasprostranennost' hronicheskoj serdechnoj nedostatochnosti v Evropejskoj chasti RF (dannye issledovanija «JePOHA – HSN»). ZhSN. 2006; 3 (7): 112–5.
  3. Paulus WJ, Tschope C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013; 62: 263–71.
  4. Taqueti VR, Ridker PM. Inflammation, coronary flow reserve, and microvascular dysfunction: moving beyond cardiac syndrome X. JACC Cardiovasc Imaging. 2013; (6): 668–71.
  5. Crea F, Merz CNB, Beltrame JF, et al. Coronary Vasomotion Disorders International Study Group. The parallel tales of microvascular angina and heart failure with preserved ejection fraction: a paradigm shift. Eur Heart J. 2017; (38): 473–77.
  6. Wei J, Nelson MD, Szczepaniak EW, et al. Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in women Am J Physiol Heart Circ Physiol. 2016; 310 (1): H14–H1.
  7. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016; (37): 2129–200.
  8. Redfield MM. Heart failure with preserved ejection fraction. N Engl J Med. 2016; (375): 1868–77.
  9. Van Krajj DJ, van Pol PE, Ruiters AW, et al. Diagnosing diastolic heart failure. Eur J Heart Fail. 2002; 4 (4): 419–30.
  10. Kato S, Saito N, Kirigaya H, et al. Impairment of coronary flow reserve evaluated by phase contrast cine-magnetic resonance imaging in patients with heart failure with preserved ejection fraction. J Am Heart Assoc. 2016; (5): e002649.
  11. Srivaratharajah K, Coutinho T, Liu P, et al. Reduced myocardial flow in heart failure patients with preserved ejection fraction. Circ Heart Fail. 2016; 9 (7): e002562.
  12. Isaaz K, Bruntz JF, Paris D, et al. Abnormal coronary flow velocity pattern in patients with left ventricular hypertrophy, angina pectoris, and normal coronary arteries: A transesophageal Doppler echocardiographic study. American Heart Journal. 1994; 128 (3): 500–10.
  13. Kaski JC, Rosano GMC, Collins P, et al. Cardiac syndrome X: clinical characteristics and left ventricular function. Journal of the American College of Cardiology. 1995; (25): 807–14.
  14. Nelson MD, Szczepaniak LS, Weiet J, al. Diastolic Dysfunction in Women With Signs and Symptoms of Ischemia in the Absence of Obstructive Coronary Artery Disease A Hypothesis-Generating Study. Circ Cardiovasc Imaging. 2014; (7): 510–6.
  15. Wu Y, Tadamura E, Yamamuro M, et al. Estimation of global and regional cardiac function using 64-slice computed tomography: a comparison study with echocardiography, gated-SPECT and cardiovascular magnetic resonance. Int J Cardiol. 2008; 128 (1): 69–76.