ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
OPINION
Adenosine-to-inosine RNA editing may be implicated in human pathogenesis
About authors
1 Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia
2 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Anna A. Kliuchnikova
Pogodinskaya 10, bld. 8, Moscow, 119121; moc.liamg@avokinhcuilk.a
About paper
Funding: the work was performed within The Programme for fundamental scientific research of state science academies for 2013–2020.
Author contribution: both authors have contributed equally to manuscript writing.
Received: 2018-08-13
Accepted: 2019-04-06
Published online: 2019-04-17
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Fig. 1. ADAR effects associated with human diseases. Changes in ADAR1 activities are assiciated with immune protection against viral infections and inflammation and with certain types of cancer; RNA editing in glutamate receptors normally occurs in CNS. ADAR2 effects are associated with both positive and negative impacts on
tumor progression while its deficiency may cause various CNS disorders
