2019 / 03

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DOI: 10.24075/brsmu.2019.044
Copyright: © 2019 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Toxicity of 13C-labeled linoleic and linolenic acids for diagnostic breath tests

Tynio YaYa1, Morozova GV2, Biryukova YuK3,4, Trubnikova EV3, Zylkova MV4, Sivokhin DA5, Ivanov KP6, Pozdniakova NV7, Kazakova EA8, Mutnykh ES9, Shevelev AB9,10
About authors

1 Russian State University of Physical Education, Sport, Youth and Tourism, Moscow, Russia

2 Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia

3 Kursk State University, Kursk, Russia

4 Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, Moscow, Russia

5 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

6 Bakulev Center for Cardiovascular Surgery Moscow, Russia

7 Blokhin National Medical Research Center of Oncology, Moscow, Russia

8 National Research University Higher School of Economics, Moscow, Russia

9 Vavilov Institute of General Genetics, Moscow, Russia

10 Plekhanov Russian University of Economics, Moscow, Russia

Correspondence should be addressed: Yulia K. Biryukova
Kosygina 4, Moscow, 119334; ur.liam@alu-avokuirib

About paper

Funding: this study was part of the State Project 0112-2019-0001 on Genomic studies and genetic polymorphism of the cell, organism and population headed by Yankovsky NK.

Author contribution: Tynio YaYa, Morozova GV — synthesis of 13C-labeled linoleic acid; Biryukova YuK — blood biochemistry tests; Trubnikova EV — statistical analysis; Zylkova MV — preparation of histological slides; Sivokhin DA — literature analysis, manuscript draft; Ivanov KP — animal sacrifice and necropsy; Pozdniakova NV, Mutnykh ES — acute toxicity tests of 13C-labeled acids following their single administration; Kazakova EA — subchronic toxicity tests of 13C-labeled acids; Shevelev AB — study conception, analysis and discussion of its results.

Received: 2019-06-24 Accepted: 2019-06-30 Published online: 2019-06-30
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Table 1. Body weight dynamics of male rats that received 13C-labeled linoleic and linolenic acids by intragastric gavage for 2 weeks
Table 2. Body weight dynamics of female rats that received 13C-labeled linoleic and linolenic acids by intragastric gavage for 2 weeks
Table 3. Blood count in rats that received 13C-linoleic acid for 2 weeks
Table 4. Total protein concentrations (g/L) in the blood serum of rats that received 13C-linoleic acid for 2 weeks
Table 5. Enzymic activity and total bilirubin levels in the blood serum of male rats that received 13C-linoleic acid for 2 weeks