ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
The accuracy of predicting eye and hair pigmentation based on genetic markers in Russian populations
About authors
1 Research Center for Medical Genetics, Moscow, Russia
2 Vavilov Institute of General Genetics, RAS, Moscow
3 Biobank of North Eurasia, Moscow, Russia
4 Moscow Institute of Physics and Technology, Moscow, Russia
5 Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia
6 Institute of Anthropology and Ethnography, Moscow, Russia
7 Anuchin Research Institute and Museum of Anthropology, Moscow, Russia
Correspondence should be addressed: Elena V. Balanovska
Moskvorechie, 1, Research Centre for Medical Genetics, Moscow, 115522; ur.liam@aksvonalab
About paper
Funding: the study was supported by the Ministry of Science and Education of the Russian Federation (State contract 011–17 dated 26.09.2017) as part of the Union State Research and Technical Project DNA-based identification, which included genotyping and phenotyping of European samples and preparation of this manuscript, and the State assignment of the Ministry of Science and Higher Education of the Russian Federation for the Research Centre for Medical Genetics (phenotyping of Siberian samples, creating a database, data analysis).
Acknowledgements: we thank all donors participating in our study. DNA samples and anthropological images were provided by the Biobank of North Eurasia.
Author contribution: Balanovska EV — supervision and study design; Petrushenko VS, Gorin IO — bioinformatic analysis, literature analysis, manuscript preparation; Maurer AM, Leybova NA — phenotyping of the samples; Kagazezheva ZhA — phenotyping of the samples, photography, photo processing, tabular data processing; Balanovsky OP, Markina NV — manuscript preparation; Kostryukova ES — genotyping.
Received: 2019-10-22
Accepted: 2019-10-26
Published online: 2019-10-28
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Table 1. Phenotypes (eye and hair color) identified from anthropological images (check PDF for full image)
Table 2. Genotypes of markers included in the HIrisPlex panel for eye and hair color prediction (check PDF for full image)
Table 3. Parameters of prediction accuracy of HIrisPlex for Western European populations and Russia
Table 4. Prediction accuracy of HIrisPlex for Russian regions
Table 5. Phenotypes (eye and hair color) predicted from genotypes included in the HIrisPlex panel (check PDF for full image)
