ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Columnar metaplasia and Barrett’s esophagus: morphological heterogeneity and immunohistochemical phenotype
About authors
1 Research Institute of Human Morphology, Moscow, Russia
2 Municipal Clinical Hospital no. 31, Moscow, Russia
3 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Ludmila M. Mikhaleva
Tsyuryupy 3, Moscow, 117418; ur.xednay@mlavelahkim
About paper
Author contribution: Mikhaleva LM — planned and supervised the study; provided equipment for the study; analyzed the obtained results; Voytkovskaya KS — analyzed the literature; collected, analyzed and interpreted the obtained data; processed microphotographs and wrote the manuscript; Fedorov ED — examined the patients; performed EGD and biopsy; analyzed and summarized the data; Shidiy-Zakrua AV — examined the patients, performed EGD and biopsy; Birukov AE — and Gracheva NA — performed pathological examination; Guschin MY — analyzed the literature.
Received: 2019-12-03
Accepted: 2019-12-18
Published online: 2019-12-26
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Fig. 1. Prevalence of different metaplasia types in CM segments extending
< 1 cm above GEJ
Fig. 2. The relative number of goblet cells in CM segments extending < 1 cm
above GEJ
Fig. 3. Prevalence of different types of columnar metaplasia in different parts of
the biopsied segment > 1 cm above GEJ, including BE
Fig. 4. The relative number of goblet cells in BE segments.
Fig. 5. The relative number of different metaplasia types in CM segments
< 1 cm and > 1 cm above GEJ
Fig. 6. The relative number of goblet cells in CM segments < 1 cm above GEJ
and in BE segments
Fig. 7. А. Low-grade esophageal dysplasia in patients with BE. B. High-grade esophageal dysplasia in patients with CM > 1 cm above GEJ. Staining: hematoxylineosin;
magnification ×200
