2020 / 01

Next Paper
DOI: 10.24075/brsmu.2020.010

ORIGINAL RESEARCH

Study of the new 4-phenylpyrrolidinone-2 derivative pharmacokinetics and neuroprotective effect in the ischemic stroke animal model

Borozdenko DA, Lyakhmun DN, Golubev YaV, Tarasenko DV, Kiseleva NM, Negrebetsky VV
About authors

Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Denis A. Borozdenko
Ostrovityanova, 1, Moscow, 117997; ude.hcetsyhp@oknedzorob

About paper

Funding: the study was performed as a part of the 2018–2020 Pirogov Russian National Research Medical University public assignment, R&D registration № АААА-А18-118051590108-1.

Acknowledgements: to Kamkin AG PhD, head of the department of Physiology of the Faculty of Biomedicine, head of the laboratory of Electrophysiology of the Institute of Translational Medicine of Pirogov Russian National Research Medical University for the opportunity to use the equipment of the Scientific and Educational Center for the study of molecular and cellular mechanisms of hypoxia and ischemia; to Abakumov MA PhD, associate professor of the department of Medical Nanobiotechnology of the Faculty of Biomedicine, for his assistance in modelling, MRI scanning and interpretation of the results.

Author contribution: Borozdenko DA — working with animals, primary data acquisition and analysis, manuscript writing; Lyakhmun DN — working with animals, functional testing; Golubev YaV — substance concentration analysis; Tarasenko DV — synthesis of substance; Kiseleva NM — study design, study management, manuscript preparation; Negrebetsky VadV — study design, study management.

Received: 2020-01-28 Accepted: 2020-02-11 Published online: 2020-02-23
|
  1. Samorodskaja IV, Zajratjanc OV, Perhov VI, Andreev EM, Vajsman DSh. Dinamika pokazatelej smertnosti naselenija ot ostrogo narushenija mozgovogo krovoobrashhenija v Rossii i SShA za 15-letnij period. Arhiv patologii. 2018; 80 (2): 30–7. https://doi.org/10.17116/ patol201880230-37
  2. The top 10 causes of death. World Health Organization 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/ the-top-10-causes-of-death
  3. Gupta S, Sharma U, Jagannathan NR, Gupta YK. Neuroprotective effect of lercanidipine in middle cerebral artery occlusion model of stroke in rats. Exp Neurol. 2017; (1): 25–37. DOI:10.1016/j. expneurol.2016.10.014.
  4. Cramer SC. Drugs to enhance motor recovery after stroke. Stroke. 2015; 46 (10): 2998–3005 DOI:10.1161/STROKEAHA.115.007433.
  5. Shakova FM, Kalinina TI, Gulyaev MV, Romanova GA. Neyroprotektivnyy i antiamnesticheskiy effekty kombinirovannoy terapii pri ishemicheskom povrezhdenii prefrontal'noy kory v eksperimente. Patologicheskaya fiziologiya i eksperimental'naya terapiya. 2018; 62 (2): 39–45. DOI:10.25557/0031- 2991.2018.02.39-45.
  6. Negrebeckij VV, Kramarova EP, Shipov AG, Baukov JuI, Shmigol TA, Kiseleva NM. Proizvodnoe 4-fenilpirrolidinona-2, soderzhashhaja ego kompozicija s nootropnoj aktivnost'ju, sposob ih poluchenija i sposob lechenija ili profilaktiki narushenij nervnoj sistemy. Patentoobladatel': GBOU VPO RNIMU im. N.I. Pirogova Minzdrava Rossii. Patent RF № 2611623. 28.02.2017.
  7. Filimonov DA, Druzhilovskiy DS, Lagunin AA, Gloriozova TA, Rudik AV, Dmitriev AV, et al. Computer-aided prediction of biological activity spectra for chemical compounds: opportunities and limitation. Biomed Chem Res Methods. 2018; 1 (1): 4–8. DOI:10.18097/BMCRM00004.
  8. Rukovodstvo po provedeniju doklinicheskih issledovanij lekarstvennyh sredstv. Chast'1. M.: Grif i K, 2012; 944 p.
  9. Koizumi J. Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke. 1986; (8): 1–8.
  10. Veinberg G, Vorona M, Zvejniece L, Vilskersts R, Vavers E, Liepinsh E, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2- oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorganic Med Chem. 2013; 21 (10):2764–71. DOI:10.1016/j.bmc.2013.03.016.
  11. Gubskiy IL, Namestnikova DD, Cherkashova EA, Chekhonin VP, Baklaushev VP, Gubsky LV, et al. MRI Guiding of the middle cerebral artery occlusion in rats aimed to improve stroke modeling. Transl Stroke Res. 2018; 9 (4): 417–25.
  12. Lu M, Chen J, Lu D, Yi L, Mahmood A, Chopp M. Global test statistics for treatment effect of stroke and traumatic brain injury in rats with administration of bone marrow stromal cells. J Neurosci Methods [Internet]. 2003; 128 (1–2): 183–90.
  13. Buresh Ya, Bureshova O, Khyuston D P. Metodiki i osnovnye eksperimenty po izucheniyu mozga i povedeniya. Vysshaya shkola. 1991; 32 (1):119–22.
  14. Sestakova N, Puzserova A, Kluknavsky M, Bernatova I. Determination of motor activity and anxiety-related behaviour in rodents: Methodological aspects and role of nitric oxide. Interdisciplinary Toxicology. 2013; 6 (3):126–35. DOI:10.2478/ intox-2013-0020.
  15. Goyal M, Menon BK, Van Zwam WH, Dippel DWJ, Mitchell PJ, Demchuk AM, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: A meta-analysis of individual patient data from five randomised trials. Lancet. 2016; 387 (10029): 1723–31. DOI:10.1016/S0140-6736(16)00163-X.
  16. Szelenberger R, Kostka J, Saluk-Bijak J, Miller E. Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery. Curr Neuropharmacol [Internet]. 2020; 18(1): 51–64. DOI:10.2174/1570159X17666190726104139.
  17. Shipov AG, Kramarova EP, Negrebetskiy VV, Pogozhikh SA, Akhapkina VI, Baukov YuI. Metody sinteza, molekulyarnaya i kristallicheskaya struktura fenotropila. Vestnik RGMU. 2006; (1): 56–61.
  18. Golubitskiy GV, Ivanov VM. Analiz siropa Nootsetam metodom gradientnoy vysokoeffektivnoy zhidkostnoy khromatografii. Vestnik Moskovskogo universiteta. Khimiya. 2009; 50 (3): 180–4.
  19. Instrukcija po primeneniju lekarstvennogo preparata dl medicinskogo primenenija Piracetam. Ministerstvo zdravoohranenija RF. Available at: https://backgrls.pharmportal.ru/storage/instructions/%D0%A0_ N000577_01/InstrImg_0000061664/%D0%A0_N000577_01[2014]_0.pdf
  20. Antonova MI, Prokopov AA, Akhapkina VI, Berlyand AS. Eksperimental'naya farmakokinetika fenotropila u krys. Khimiko-farmatsevticheskiy zhurnal. 2003; 37 (11): 6–8.
  21. Vostrikov VV. Place of piracetam in the modern practice of medicine. Rev Clin Pharmacol Drug Ther. 2017; 15 (1):14–25. DOI:10.17816/rcf15114-25.