ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2020 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
OPINION
On the unpredictability of outcomes of immunotherapy and preventive immunization against COVID-19
About authors
Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Igor V. Chebotar
Ostrovityanova, 1, Moscow, 117997; ur.xednay@nnrazin
About paper
Author contribution: the authors equally contributed to the manuscript
Received: 2020-04-21
Accepted: 2020-04-28
Published online: 2020-04-30
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This article analyzes the possibility of employing immunotherapy and preventive immunization to fight COVID-19. The authors think that treatment and prevention of the infection with anti-SARS-CoV-2 antibodies can have unpredictable outcomes. Although these antibodies can neutralize virus antigens (S-proteins), they also have the ability to enhance virus entry into the host cell. The article emphasizes the importance of solid evidence of efficacy and safety for candidate anti-COVID-19 therapies and protective measures.
Keywords: coronavirus, immunotherapy, COVID-19, SARS-CoV-2, antibodies, preventive immunization