Funding: the study was conducted under the state assignment АААА-А18-118053190012-9 (Development of assays for early diagnosis of breast and ovarian cancers based on the analysis of RNA circulating in the peripheral blood).

Acknowledgements: we thank the Center for Precision Genome Editing and Genetic Technologies for Biomedicine of Pirogov Russian National Medical Research University (Moscow, Russia) for their help in interpreting the data and analyzing some of the results.

Author contribution: Lolomadze EA — literature analysis and preparation of the manuscript draft; Kometova VV, Rodionov VV — editing and manuscript revision