ORIGINAL RESEARCH

IgM and IgG antibodies against SARS-CoV-2 in neonates born to mothers with COVID-19

Semeshkin AA, Vechorko VI, Silaev BV, Levchuk NN, Polikarpova SV, Averkov OV
About authors

Filatov City Clinical Hospital № 15, Moscow, Russia

Correspondence should be addressed: Borislav V. Silaev
Veshnyakovskaya, 23/1, Moscow, 111517; ur.xednay@vealisrd

About paper

Compliance with ethical standards: the study was approved by the Ethics Committee of Filatov City Clinical Hospital No. 15 (Protocol No. 5 dated May12, 2020). Informed consent was obtained from all study participants or their legal representatives.

Author contribution: Semeshkin AA — data acquisition, blood collection for antibody tests in neonates, nasopharyngeal swab collection for PCR tests in neonates, analysis of the obtained data, manuscript preparation; Vechorko VI, Averkov OV — study planning, analysis of the obtained data; Silaev BV — study planning, blood collection for antibody tests in mothers, nasopharyngeal swab collection for PCR tests in mothers, data analysis, literature analysis, manuscript preparation; Levchuk NN — data acquisition, laboratory tests for IgM and IgG, analysis of the obtained data; Polikarpova SV — data acquisition, PCR tests in mothers and neonates, literature analysis, analysis of the obtained data.

Received: 2020-05-26 Accepted: 2020-06-13 Published online: 2020-06-26
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  1. Kimberlin DW, Stagno S. Can SARS-CoV-2 Infection Be Acquired In Utero? More Definitive Evidence Is Needed. JAMA. 2020; 323 (18): 1788–9. DOI: 10.1001/jama.2020.4868.
  2. Shaoshuai Wang, Lili Guo, Ling Chen, Weiyong Liu, Yong Cao, Jingyi Zhang, et al. A Case Report of Neonatal 2019 Coronavirus Disease in China. Clinical Infectious Diseases, ciaa225, Available from: https://doi.org/10.1093/cid/ciaa225.
  3. Dong L, Tian J, He S, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. Published March 26, 2020. DOI: 10.1001/jama.2020.4621.
  4. Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during Pregnancy and Possible Vertical Transmission [published online ahead of print, 2020 Apr 18]. Am J Perinatol. 2020; 10.1055/s-0040-1710050. DOI: 10.1055/s-0040-1710050.
  5. World Health Organization. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases: interim guidance 2020. Posted January 17, 2020. Accessed March 5, 2020. Available from: https://www.who.int/publications-detail/ laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases- 20200117.
  6. Vremennye metodicheskie rekomendacii MZ RF. «Profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii (COVID-19)» versija # 6 (24.04.2020). Available from (aktivna na 09 ijunja 2020 g.): http://www.garant.ru/products/ipo/prime/doc/74067237/. Russian.
  7. Vremennaja instrukcija MZ RF ot 10.04.2020 g. # 17-1/I1-2004 «Vremennaja instrukcija po voprosu zabora biologicheskogo materiala u vseh pacientov s podozreniem na pnevmoniju ili s podtverzhdennoj pnevmoniej, postupajushhih na gospitalizaciju v stacionary». Available from (aktivna na 11 ijunja 2020 g.): http:// base.garant.ru/74167237/. Russian.
  8. Zeng H, Xu C, Fan J, et al. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. 2020; 323 (18): 1848–9. DOI: 10.1001/jama.2020.4861.
  9. Parazzini F, Bortolus R, Mauri PA, Favilli A, Gerli S, Ferrazzi E. Delivery in pregnant women infected with SARS-CoV-2: A fast review. Int J Gynaecol Obstet. 2020 Jul; 150 (1): 41–46. DOI: 10.1002/ijgo.13166. Epub 2020 May 1.
  10. Liu P, Zheng J, Yang P, Wang X, Wei C, Zhang S, et al. The Immunologic Status of Newborns Born to SARS-CoV2-infected Mothers in Wuhan, China J Allergy Clin Immunol. 2020 May 10: S0091-6749(20)30640-0. DOI: 10.1016/j.jaci.2020.04.038.