ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2020 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
IgM and IgG antibodies against SARS-CoV-2 in neonates born to mothers with COVID-19
About authors
Filatov City Clinical Hospital № 15, Moscow, Russia
Correspondence should be addressed: Borislav V. Silaev
Veshnyakovskaya, 23/1, Moscow, 111517; ur.xednay@vealisrd
About paper
Compliance with ethical standards: the study was approved by the Ethics Committee of Filatov City Clinical Hospital No. 15 (Protocol No. 5 dated May12, 2020). Informed consent was obtained from all study participants or their legal representatives.
Author contribution: Semeshkin AA — data acquisition, blood collection for antibody tests in neonates, nasopharyngeal swab collection for PCR tests in neonates, analysis of the obtained data, manuscript preparation; Vechorko VI, Averkov OV — study planning, analysis of the obtained data; Silaev BV — study planning, blood collection for antibody tests in mothers, nasopharyngeal swab collection for PCR tests in mothers, data analysis, literature analysis, manuscript preparation; Levchuk NN — data acquisition, laboratory tests for IgM and IgG, analysis of the obtained data; Polikarpova SV — data acquisition, PCR tests in mothers and neonates, literature analysis, analysis of the obtained data.
Received: 2020-05-26
Accepted: 2020-06-13
Published online: 2020-06-26
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Immunity against the novel coronavirus infection in neonates born to mothers with PCR-confirmed COVID-19 is an understudied field of research. The aim of this study was to analyze the levels of IgM and IgG antibodies against SARS-CoV-2. The study was carried out in 20 mothers aged 19 to 39 years and 21 neonates (including a pair of twins). Babies born to mothers with elevated IgM and IgG against SARS-CoV-2 also had elevated IgG. There is a hypothesis that anti-SARS-CoV-2 IgM are not passed on to the child across the placenta. In all cases studied in this work, neonates were PCR-negative for the virus, which suggests the absence of vertical COVID-19 transmission. Further research is needed.
Keywords: placenta, IgG, COVID-19, SARS-CoV-2, novel coronavirus, transmission routes, neonate, mother, neonatal immunity, immunoglobulin, IgM