2020 / 04

DOI: 10.24075/brsmu.2020.052

ORIGINAL RESEARCH

Thrombogenicity in patients with ischemic stroke and pre-existing polycythemia vera

Tanashyan MM1, Shabalina AA1, Roitman EV1, Vavilova TV2, Kuznetsova PI1
About authors

1 Research Center of Neurology, Moscow, Russia

2 Almazov National Medical Research Centre, Saint Petersburg, Russia

Correspondence should be addressed: Alla A. Shabalina
Volokolamskoe shosse, 80/1, Moscow, 125367; ur.ygoloruen@anilabahs

About paper

Compliance with ethical standards: the study was approved by the local Ethics Committee (Protocol № 1–4/18 dated February 7, 2018). Informed consent was obtained from all study participants.

Author contribution: Tanashyan MM — study concept and design; discussion and manuscript preparation; Shablina AA — literature analysis; data acquisition and statistical analysis; results discussion; Roitman EV, Vavilova TV — literature analysis; results discussion; Kuznetsova PI — patient histories; results discussion.

Received: 2020-08-11 Accepted: 2020-08-25 Published online: 2020-09-01
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Fig. 1. Hemostasis profiles of patients in the hyperacute IS stage. ADAMTS-13 and fibrinogen concentrations and the tPA/PAI-1 ratio are shown concisely to fit into the overall hemostasis profile picture
Fig. 2. Hemostasis profiles of main group patients in the hyperacute IS phase and in the long-term stroke period
Table 1. A correlation matrix showing effects of JAK2 V617F allele burden on the laboratory parameters in patients with PV in the hyperacute stroke phase
Table 2. Thrombotic and hemorrhagic complications in patients detected on the follow-up examination 16–18 months after IS
Note: n/a — data not available.