Difficulties in differential diagnosis of cutaneous manifestations in patients with coronavirus infection

Tairova RT1,2, Gaydina TA1,2, Dvornikov AS2, Tazartukova AD1, Lyang OV1
About authors

1 Federal Center for Brain and Neurotechnology of FMBA of Russia, Moscow, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Tatiana A. Gaydina
Ostrovityanova, 1, Moscow, 117997; ur.xednay@924cod

About paper

Compliance with ethical standards: the patient gave informed consent to medical treatment and publication of this case report.

Author contribution: Tairova RT, Gaydina TA: interpretation of the obtained data, manuscript draft; Dvornikov AS: literature analysis; Tazartukova AD: interpretation of the obtained data; Lyang OV: manuscript draft.

Received: 2020-09-23 Accepted: 2020-10-08 Published online: 2020-10-21

Patients with severe SARS-CoV-2 infection (COVID-19) and multiple comorbidities should be monitored for possible adverse reactions to prescribed drugs, including drug eruptions (DE) at any stage of treatment. Below, we describe a clinical case of a 92-year-old female patient with severe PCR-confirmed COVID-19. The patient was treated with amoxicillin/clavulanic acid, moxifloxacin, acetylcysteine, and sodium enoxaparin. On day 9 into treatment, the patient developed moderately itching macular rashes showing a tendency to coalesce, but overall showed no signs of deterioration. On day 15, the rashes regressed, following a short course of dexamethasone and chloropyramine. This kind of skin reaction might have been provoked by β-lactams and fluoroquinolones included in the treatment regimen, a secondary bacterial infection, compromised immunity due to advanced age, and high viral load associated with dermatological symptoms. Delayed onset of skin symptoms might be regarded as a marker of COVID-19 severity.

Keywords: COVID-19, SARS-CoV-2, coronavirus infection, SARS-COV-2, skin manifestations, toxidermia, drug eruptions