ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2020 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Analysis of the polymorphic variants of ADRB2 gene association with the β2-agonists response in patients with a rare theratype of asthma
About authors
National Research Center Institute of Immunology of the Federal Medical-Biological Agency, Moscow, Russia
Correspondence should be addressed: Ksenia S. Pavlova
Kashirskoe shosse, 24, Moscow, 115522; moc.liamg@lacideminesk
About paper
Funding: the study was supported by the Russian Foundation for Basic Research as part of the Project #19-33-90076.
Acknowledgement: we would like to thank the Biomedicine Center for High-Precision Editing and Genetic Technologies of Pirogov Russian National Research Medical University (Moscow, Russia) for access to the molecular genetics systems.
Author contribution: Mdinaradze DS, Pavlova KS, Kurbacheva OM — selection of patients, clinical laboratory and instrumental examinations, collection of biological material; Kozlov IB, Kofiadi IA — development of the new PCR test system for analysis of the ADRB2 gene polymorphic variants, genetic testing execution.
Compliance with ethical standards: the study was approved by the ethics committee of the Institute of Immunology of the Federal Medical-Biological Agency (Minutes #13 of October 16, 2017); all patients signed voluntary consent to participate in the study.
Received: 2020-11-25
Accepted: 2020-12-09
Published online: 2020-12-27
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