ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Levels of miR-374 increase in BeWo b30 cells exposed to hypoxia
About authors
1 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
2 National Research University Higher School of Economics, Moscow, Russia
3 Translational Technology Center, Moscow
4 Troitsk Research and Development Center, Moscow
Correspondence should be addressed: Evgeny N. Knyazev
Miklouho-Maclay, 16/10, Moscow, 117437; moc.liamg@gvevezaynk
About paper
Funding: This work was supported by the Russian Science Foundation (Grant № 19-74-00145).
Author contribution: Knyazev EN analyzed the literature, planned the study, collected and interpreted the obtained data, and wrote the manuscript; Paul SYu analyzed the literature and the obtained data and wrote the manuscript.
Compliance with ethical standards: the study complied with the Declaration of Helsinki.
Received: 2021-04-20
Accepted: 2021-04-28
Published online: 2021-04-30
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Fig. 1. Positions of microRNA binding sites on a fragment of a 3'-untranslated region of FOXM1 mRNA (transcription variant 2). Nucleotide numbers are represented by 4-digit numbers. 1 — binding sites for hsa-miR-374a-5p and hsa-miR-374b-5p; 2 — a binding site for hsa-miR-21-5p
Table 1. Expression of key genes involved in response to hypoxia in BeWo b30 cells (based on sequencing data)
Note: * — designates FDR-p > 0.05; for other genes, FDR-p < 0,05.
Table 2. Expression of key genes involved in response to hypoxia in BeWo b30 cells (based on PCR data)
Note: * — FDR-p < 0,05.
Table 3. MiRNA with significantly changed expression after exposure to OD
Table 4. MiRNA with significantly changed expression after exposure to CoCl2
