ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
New non-invasive approaches to the diagnosis of lymph node metastases from breast cancer by mass spectrometry
About authors
1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
2 V. L. Talrose Institute for Energy Problems of Chemical Physics, Moscow, Russia
Correspondence should be addressed: Vladimir E. Frankevich
Oparina, 4, Moscow, 117997, Russia; moc.liamg@hciveknarfv
About paper
Funding: the study was funded by RFBR and National Natural Science Foundation of China within the framework of the scientific project № 19-515-55021
Compliance with ethical standards: the study was approved by the Ethics Committee of Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol № 9 dated November 22, 2018); the study was carried out in accordance with the requirements of the Declaration of Helsinki, International Council for Harmonisation (ICF), Good Clinical Practice (GCP) guidelines, Federal Law 323-FZ dated November 21, 2011 “On the Basics of Protecting the Health of Citizens in the Russian Federation”; the informed consent was submitted by all patients.
Received: 2021-10-26
Accepted: 2021-11-08
Published online: 2021-11-10
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Fig. 1. Graphs of counts made for orthogonal projections to latent structures in the positive ion mode (А) and in the negative ion mode (B). The samples obtained from patients with regional metastases are marked with red dots, and the samples obtained from patients with no metastasis are marked with blue dots
Fig. 2. ROC curve plotted during cross-validation of the diagnostic model in the positive ion mode (А) and negative ion mode (B)
Table 1. Relative intensities (arbitrary units) of lipids, showing significant differences in plasma in the presence or absence of metastases, in the positive ion mode
Table 2. Relative intensities (conventional units) of lipids, showing significant differences in plasma in the presence or absence of metastases, in the negative ion mode
Table 3. Compounds used to build the logistic regression model, β coefficients (conventional units), confidence interval (CI) for β coefficients (conventional units), Wald test, likelihood that coefficient p differs from zero in the positive ion mode
Table 4. Compounds used to build the logistic regression model, β coefficients (conventional units), confidence interval (CI) for β coefficients (conventional units), Wald test, likelihood that coefficient p differs from zero in the negative ion mode
