2022 / 01

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DOI: 10.24075/brsmu.2022.002

ORIGINAL RESEARCH

Visual analysis of nigrosome-1 in the differential diagnosis of Parkinson's disease and essential tremor

Moskalenko AN, Filatov AS, Fedotova EYu, Konovalov RN, Illarioshkin SN
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Anna N. Moskalenko
Volokolamskoe sh., 80, Moscow, 125367, Russia; ur.relbmar@nrek_kin_anna

About paper

Author contribution: Moskalenko AN — clinical assessment, data acquisition and interpretation, literature analysis, manuscript preparation; Filatov AS — data analysis and interpretation, manuscript preparation; Konovalov RN — data analysis and interpretation, study planning and supervision; Fedotova EYu, Illarioshkin SN — study planning and supervision.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (Protocol № 2–5/20 dated March 18, 2020). Informed consent was obtained from all study participants.

Received: 2021-12-22 Accepted: 2022-01-18 Published online: 2022-01-31
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Fig. 1. Susceptibility-weighted MR images in the axial plane; slices pass through the cerebral peduncles. The substantia nigra is hypointense on SWI sequences, whereas nigrosomes-1 (yellow circles) are hyperintense. The figure shows different patterns of nigrosome-1 appearance in patients with PD (A — 0 points, B — 1 point (nigrosome-1 is reduced in volume on the left), C — 2 points, D — 3 points)
Fig. 2. Results of non-invasive nigrosome-1 assessment in patients with PD and ET
Table. Demographic characteristics of the patients