ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Visual analysis of nigrosome-1 in the differential diagnosis of Parkinson's disease and essential tremor
About authors
Research Center of Neurology, Moscow, Russia
Correspondence should be addressed: Anna N. Moskalenko
Volokolamskoe sh., 80, Moscow, 125367, Russia; ur.relbmar@nrek_kin_anna
About paper
Author contribution: Moskalenko AN — clinical assessment, data acquisition and interpretation, literature analysis, manuscript preparation; Filatov AS — data analysis and interpretation, manuscript preparation; Konovalov RN — data analysis and interpretation, study planning and supervision; Fedotova EYu, Illarioshkin SN — study planning and supervision.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (Protocol № 2–5/20 dated March 18, 2020). Informed consent was obtained from all study participants.
Received: 2021-12-22
Accepted: 2022-01-18
Published online: 2022-01-31
|
Fig. 1. Susceptibility-weighted MR images in the axial plane; slices pass through the cerebral peduncles. The substantia nigra is hypointense on SWI sequences, whereas nigrosomes-1 (yellow circles) are hyperintense. The figure shows different patterns of nigrosome-1 appearance in patients with PD (A — 0 points, B — 1 point (nigrosome-1 is reduced in volume on the left), C — 2 points, D — 3 points)
Fig. 2. Results of non-invasive nigrosome-1 assessment in patients with PD and ET
Table. Demographic characteristics of the patients
