2022 / 02

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DOI: 10.24075/brsmu.2022.019

ORIGINAL RESEARCH

Footprints of interaction among Finniс-speaking, Slavic, and Turkic-speaking populations in modern gene pool and their reflection in pharmacogenetics

Balanovska EV1,2,3, Gorin IO1, Ponomarev GYu2, Pylev VYu1,3, Petrushenko VS1, Markina NV2, Mamaeva AD2, Larin AK4, Agdzhoyan AT2
About authors

1 Bochkov Research Centre of Medical Genetics, Moscow, Russia

2 Vavilov Institute of General Genetics, Moscow, Russia

3 Biobank of North Eurasia, Moscow, Russia

4 Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia

Correspondence should be addressed: Elena V. Balanovska
Moskvorechie, 1, 115522, Moscow, Russia; ur.liam@aksvonalab

About paper

Funding: the study was supported by RFBR grant 20-29-01017 Ancient DNA (bioinformatics analysis), RSF grant 21-14-00363 (analysis of pharmacogenetics markers), and State Assignment of the Ministry of Science and Higher Education of the Russian Federation to Vavilov Institute of General Genetics (cartographic analysis) and Bochkov Research Centre of Medical Genetics (data interpretation).

Acknowledgements: the authors thank all sample donors who participated in this study and the Biobank of North Eurasia for the access to DNA collections.

Received: 2022-04-01 Accepted: 2022-04-16 Published online: 2022-04-26
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  1. Sedov VV. Osvoenie slavyanami Vostochnoevropejskoj ravniny. V knige: Vostochnye slavyane. Antropologiya i ehtnicheskaya istoriya. M.: Nauchnyj mir, 1999; s. 153–160. Russian.
  2. Balanovskaya EV, Balanovskij OP. Russkij genofond na Russkoj ravnine. M.: Luch, 2007. Russian.
  3. Leontev AE, Ryabinin EA. Ehtapy i formy assimilyacii letopisnoj meri (postanovka voprosa). Sovetskaya arxeologiya. 1980; (2): 67–79. Russian.
  4. Bejlekchi VV. Drevnosti letopisnoj muromy (pogrebal'nyj obryad i poseleniya). M.: Murom, 2005; 278 s. Russian.
  5. Alekseeva TI. Ehtnogenez vostochnyx slavyan po dannym antropologii. M.: Nauka, 1973; 329 s. Russian.
  6. Sedov VV. Drevnerusskaya narodnost': Istoriko-arxeologicheskoe issledovanie. M.: Yazyki russkoj kul'tury, 1999; 316 s. Russian.
  7. Goryunova EI. Ehtnicheskaya istoriya Volgo-Okskogo mezhdurech'ya. M.: Izd-vo AN SSSR, 1961; 264 c. Russian.
  8. Rizzi E, Lari M, Gigli E, De Bellis G, Caramelli D. Ancient DNA studies: new perspectives on old samples. Genet Sel Evol. 2012 Jul 6; 44 (1): 21. DOI: 10.1186/1297-9686-44-21.
  9. Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K et al. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature. 2014; 513: 409–413. DOI: 10.1038/nature13673.
  10. Haak W, Lazaridis I, Patterson N, Rohland N, Mallik S, Llamas B et al. Massive migration from the steppe was a source for IndoEuropean languages in Europe. Nature. 2015 Jun 11; 522 (7555): 207–11. DOI: 10.1038/nature14317.
  11. Allentoft ME, Sikora M, Sjögren KG, Rasmussen S, Rasmussen M, Stenderup J et al. Population genomics of Bronze Age Eurasia. Nature. 2015 Jun 11; 522 (7555): 167–72. DOI: 10.1038/ nature14507.
  12. Jones ER, Zarina G, Moiseyev V, et al. The Neolithic Transition in the Baltic Was Not Driven by Admixture with Early European Farmers. Curr Biol. 2017 Feb 20; 27 (4): 576–82. DOI: 10.1016/j. cub.2016.12.060.
  13. Mittnik A, Wang CC, Pfrengle S, Daubaras M, Zarina G, Hallgren F et al. The genetic prehistory of the Baltic Sea region. Nat Commun. 2018 Jan 30; 9 (1): 442. DOI: 10.1038/s41467-018-02825-9.
  14. Lamnidis TC, Majander K, Jeong C, Salmela E, Wessman A, Moiseyev V et al. Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe. Nat Commun. 2018 Nov 27; 9 (5018). DOI: 10.1038/s41467-018-07483-5.
  15. Li JZ, Absher DM, Tang H, et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science. 2008; 319 (5866): 1100–4. DOI: 10.1126/science.1153717.
  16. Novembre J, Johnson T, Bryc K, Kutalik Z, Boyko A, Auton A, et al. Genes mirror geography within Europe. Nature. 2008 Aug 31; 456: 98–101. DOI: 10.1038/nature07331.
  17. Pagani L, Lawson D, Jagoda E, Morseburg A, Eriksson A, Mitt M, et al. Genomic analyses inform on migration events during the peopling of Eurasia. Nature. 2016 Oct 13; 538 (7624): 238–42. DOI: 10.1038/nature19792.
  18. Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, et al. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538 (7624): 201–6. DOI: 10.1038/nature18964.
  19. Malaspinas AS, Westaway M, Muller C, Sousa V, Lao O, Alves I et al. A genomic history of Aboriginal Australia. Nature. 2016 Oct 13; 538 (7624): 207–14. DOI: 10.1038/nature18299.
  20. Alexander DH, Lange K. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics. 2011; 12 (1): 246. DOI: 10.1186/1471-2105-12-246.
  21. Kushniarevich A, Utevska O, Chuhryaeva M, Agdzhoyan A, Dibirova K, Uktverite I et al. Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data. PLoS ONE. 2015 Sep 2; 10 (9). PubMed PMID: 26332464. DOI: 10.1371/journal.pone.0135820.
  22. Triska Р, Chekanov N, Stepanov V, Khusnutdinova E, Arun Kumar GP, Akhmetova V. Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe. BMC Genetics. 2017 Dec 28; 18 (1): 5–20. PubMed PMID: 29297395. DOI: 10.1186/ s12863-017-0578-3.
  23. Tambets K, Yunusbayev B, Hudjashov G, Ilumäe A-M, Rootsi S, Honkola T. Genes reveal traces of common recent demographic history for most of the Uralicspeaking populations. BMC Genome Biology. 2018 Sep 21; 19 (1): 1–20. DOI: 10.1186/s13059-018-1522-1.
  24. Jeong C, Balanovsky O, Lukianova E, Kahbatkyzy N, Flegontov P, Zaporozhchenko V, et al. The genetic history of admixture across inner Eurasia. Nature ecology & evolution. 2019 Jun; 3 (6): 966–76. PubMed PMID: 31036896. DOI: 10.1038/s41559-019-0878-2.
  25. Balanovska EV, Chernevsky DK, Balanovsky OP. Svoeobrazie Novgorodskogo genofonda v kontekste narodonaseleniya evropejskoj chasti Rossii. Vestnik Novgorodskogo gosudarstvennogo universiteta. Ser.: Medicinskie nauki. 2021; 124 (3): 51–57. DOI: 10.34680/2076-8052.2021. Russian.
  26. Balanovska EV, Petrushenko VS, Koshel SM, Pocheshhova EA, Chernevsky DK, Mirzaev KB, et al. Cartographic atlas of frequency variation for 45 pharmacogenetic markers in populations of Russia and its neighbor states. Vestnik RGMU. 2020; (6): 38–50. DOI: 10.24075/brsmu.2020.080.
  27. Balanovsky OP, Gorin IO, Zapisetskaya YS, Golubeva AA, Kostryukova ES, Balanovska EV. Interactions between gene pools of russian and finnish-speaking populations from Tver region: analysis of 4 million SNP markers. Vestnik RGMU. 2020; (6): 15– 22. DOI: 10.24075/brsmu.2020.072.
  28. Balanovska EV, Zhabagin MK, Agdjoyan AT, Chuhryaeva MI, Markina NV, Balaganskaya OA, et al. Populyacionnye biobanki: principy organizacii i perspektivy primeneniya v genogeografii i personalizirovannoj medicine. Genetika. 2016; 52 (12): 1371–87. DOI: 10.7868/S001667581612002X. Russian.
  29. Alexander DH, Novembre J, Lange K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009 Sep; 19 (9): 1655–64. DOI: 10.1101/gr.094052.109.
  30. Koshel SM. Geoinformacionnye texnologii v genogeografii. V knige: Sovremennaya geograficheskaya kartografiya. M: Data+, 2012; s. 158–166. Russian.
  31. Balanovsky OP. Genofond Evropy. M.: Tovarishhestvo nauchnyx izdanij KMK, 2015. Russian.