2022 / 03

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DOI: 10.24075/brsmu.2022.028

ORIGINAL RESEARCH

Isoforms of miR-148a and miR-203a are putative suppressors of colorectal cancer

Nersisyan SA1,2
About authors

1 National Research University Higher School of Economics (HSE), Moscow, Russia

2 Institute of Molecular Biology (IMB) of the National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia

Correspondence should be addressed: Stepan A. Nersisyan
Vavilova, 7, Moscow, 117312, Russia; ur.esh@naysisrens

About paper

Funding: the study was supported by HSE Basic Research Program.

Acknowledgement: the author thanks Aleksey Galatenko of the HSE Laboratory of Molecular Physiology for the fruitful critique and valuable comments.

Compliance with ethical standards: the study complies with the ethical principles of the World Medical Association Declaration of Helsinki.

Received: 2022-04-29 Accepted: 2022-05-22 Published online: 2022-05-30
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Fig. 1. Expression distributions for 55 most highly expressed microRNA 5'-isoforms in a sample of colorectal cancer tissues. Horizontal lines in the boxes are median values, box limits correspond to lower and upper quartiles, whisker termini correspond to minimal and maximal values
Fig. 2. Regulatory network of interactions among microRNA isoforms, their targets and transcription factors. Blue, green and red colors correspond to microRNA 5'-isoforms, transcription factors and target genes, respectively. The edges are colored in accordance with the type of regulator. The vertex sizes are linearly related to degrees
Fig. 3. Strongly connected subgraph of interactions between microRNA 5'-isoforms and transcription factors. Ellipses and rectangles denote microRNA isoforms and transcription factors, respectively. Arrows correspond to expression activation, blunt-end lines correspond to expression inhibition
Table. Numbers of putative targets for highly expressed canonical microRNAs and their 5'-isoforms