2022 / 03

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DOI: 10.24075/brsmu.2022.030

ORIGINAL RESEARCH

Clinical and morphological features of non-small cell lung cancer in patients with different types of histological changes to the bronchial epithelium

Zavyalova MV1,2, Loos DM1, Pismenny DS1,2, Durova AA1, Pankova OV2, Rodionov EO2, Tuzikov SA1,2, Tashireva LA2, Perelmuter VM2
About authors

1 Siberian State Medical University, Tomsk, Russia

2 Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia

Correspondence should be addressed: Dmitry S. Pismenny
Kooperativny pereulok, 5, Tomsk, 634009, Russia; moc.liamg@yrtimd.yinnemsip

About paper

Author contribution: Pismenny DS — analysis of the literature and writing of the text; Rodionov EO, Tuzikov SA — surgery and tumor specimen collection; Pankova OV, Loos DM, Durova AA — morphological study; Tashireva LA — statistical processing of the data; Zavyalova MV, Perelmuter VM — concept and design, scientific editing of the manuscript.

Compliance with ethical standards: the study was approved by Ethical Review Board at the Siberian State Medical University (Protocol No. 5600 of 23 October 2017).

Received: 2022-05-04 Accepted: 2022-06-02 Published online: 2022-06-15
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Fig. 1. Morphological subtypes of the parenchymal component of primary tumors in adenocarcinoma (A, lepidic; B, acinar; C, papillary; D, micropapillary; E, solid; F, solitary tumor cells) and squamous cell carcinoma (G, type I; H, type II; I, type III; J, type IV; K, type V). Staining H & E, magnification ×200
Fig. 2. Morphological changes to the bronchial epithelium outside the tumor: basal cell hyperplasia, BCH (A) and squamous cell metaplasia, SM (B). Staining H&E, magnification ×200
Fig. 3. Comparative characterization of the disease progression indicators in the groups of patients with non-small cell lung cancer distinguished on the basis of morphological changes to the bronchial epithelium. A. Tumor size (T). B. Lymphogenous metastases. C. Relapses. D. Hematogenous metastases
Table 1. Clinical and morphological characterization for the groups of patients with non-small cell lung cancer distinguished on the basis of morphological changes to the bronchial epithelium
Note: a.v. — absolute value; p4 measures the consistency of equal morbidity hypothesis for men (row 3) and women (row 4) in a given group; p7 measures the consistency of equal probability hypothesis for central vs peripheral localization (rows 6 and 7, respectively) in a given group.
Table 2. Histological characterization of the primary tumors for the groups of patients with non-small cell lung cancer distinguished on the basis of morphological changes to the bronchial epithelium
Note: p3 measures the consistency of equal probability hypothesis for squamous cell carcinoma (row 3) and adenocarcinoma (row 2) in a given group; pa measures the consistency of differences in a given parameter with group a (BCH–SM–); pb measures the consistency of differences in a given parameter with group b (BCH+SM–); рc measures the consistency of differences in a given parameter with group c (BCH+SM+).