Predicting preterm birth based on vaginal microbiota assessment by real-time PCR in the first trimester

Voroshilina ES1,2, Khayutin LV2, Kudryavtseva EV1, Kovalev VV1, Plotko EE2
About authors

1 Ural State Medical University, Yekaterinburg, Russia

2 ‘Garmonia’ Medical Center, Yekaterinburg, Russia

Correspondence should be addressed: Ekaterina S. Voroshilina
Tveritina, 16, Yekaterinburg, 620100, Russia; moc.liamg@anilihsorov

About paper

Author contribution: Voroshilina ES — organization of the study, conducting real-time PCR, data analysis, writing the article; Khayutin LV — organization of the study,data analysis, patient selection, writing the article; Kudryavtseva EV, Kovalev VV — statistical processing, data analysis, writing the article; Plotko EE — organization of the study,data analysis, patient selection, writing the article.

Compliance with ethical standards: the study was approved by the Ethics Committee of Ural State Medical University, Federal State Budget Educational Institution of Higher Education under the Ministry of Health of the Russian Federation (Protocol № 7 dated March 28, 2011). All patients signed the informed written consent to participation in the study.

Received: 2022-04-28 Accepted: 2022-05-22 Published online: 2022-06-19
Fig. 1. The structure of vaginal microbiocenosis in the examined groups of pregnant women (χ2 = 19.066; p < 0.001 [1.2E-5])
Fig. 2. The value of the PRIMA index in the analyzed groups
Fig. 3. ROC curve of the PRIMA index
Fig. 4. Sensitivity and specificity at different values of the PRIMA index PRIMA index value
Table 1. CCDF when calculating the PRIMA index
Table 2. Sensitivity and specificity of the PRIMA index