ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Altered circadian expression of cytokines in blood of patients with essential hypertension following COVID-19
About authors
1 National Research Mordovia State University, Saransk, Russia
2 State Research and Development Institute of High Purity Biologicals of the Federal Medical and Biological Agency, Saint-Petersburg, Russia
Correspondence should be addressed: Olga A. Radaeva
Ulyanova, d. 26a, Saransk, 430032, Russia; ur.liam@demaveadar
About paper
Funding: supported by the grant of the Russian Science Foundation ‘Analysis of altered circadian expression of cytokines in blood of patients with essential hypertension as predictor of cardiovascular complications’, № 23-25-00147.
Author contribution: Radaeva OA — trial design, analysis of results, preparation of a manuscript; Simbirtsev AS — stating the purpose of the trial, editing; Kostina YuA — lab research, preparation of a manuscript; Iskandyarova MS — working with literature, editing; Negodnova EV — working with literature, surveillance over patients; Mashnina SV, Krasnoglazova KA, Babushkin IO — statistical treatment of data; Eremeev VV — editing.
Compliance with ethical standards: The trial was approved by the Ethics Committee of the National Research Mordovia State University (protocol № 12 as of December 14, 2008, protocol № 85 as of May 27, 2020). All patients signed a voluntary informed consent form. Biological sample (blood) was obtained in accordance with the provisions of Declaration of Helsinki of BMA (2013), protocol of Council of Europe Convention for the Protection of Human Rights and Biomedicine (1999) and additional protocol to Convention for the Protection of Human Rights and Biomedicine in the area of biomedical research (2005).
Received: 2023-11-29
Accepted: 2023-12-14
Published online: 2023-12-31
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Table 1. Analysis of cytokines in the blood of patients with EAH prior to COVID-19
Note: * — significant level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (dependent and independent samples were compared with the Wilcoxon and Mann–Whitney tests respectively) indicating time intervals (1–7:00; 2–12:00; 3–19:00; 4–00:00.)
Table 2. Analysis of cytokines in the blood of healthy people prior to COVID-19
Note: * — significant level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (dependent and independent samples were compared with the Wilcoxon and Mann–Whitney tests respectively) indicating time intervals (1–7:00; 2–12:00; 3–19:00; 4–00:00.).
Table 3. Analysis of blood cytokines levels in patients with EAH 10 days following the novel coronavirus infection
Note: * — significant level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (dependent and independent samples were compared with the Wilcoxon and Mann–Whitney tests respectively) indicating time intervals (1–7:00; 2–12:00; 3–19:00; 4–00:00.).
Table 4. Analysis of blood cytokines levels in patients with EAH 10 days following the novel coronavirus infection
Note: * — significant level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (dependent and independent samples were compared with the Wilcoxon and Mann–Whitney tests respectively) indicating time intervals (1 — 7:00; 2 — 12:00; 3 — 19:00; 4 — 00:00.).
Table 5. Analysis of blood cytokines levels in patients with EAH 6 months following the novel coronavirus infection
Note: * — significant level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (dependent and independent samples were compared with the Wilcoxon and Mann–Whitney tests respectively) indicating time intervals (1 — 7:00; 2 — 12:00; 3 — 19:00; 4 — 00:00.).
Table 6. Analysis of blood cytokines levels in patients with EAH 6 months following the novel coronavirus infection
Note: * — significant level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (dependent and independent samples were compared with the Wilcoxon and Mann–Whitney tests respectively) indicating time intervals (1 — 7:00; 2 — 12:00; 3 — 19:00; 4 — 00:00.).
