ORIGINAL RESEARCH

Effectiveness of enriching drug treatment with systemic ozone therapy in patients with post-COVID asthenic syndrome

Soldatenko AA1, Gumenyuk LN2, Berdieva DM2, Ponomarchuk EI2
About authors

1 Rein-LTD LLC, Avicenna Clinic, Simferopol, Russia

2 S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Correspondence should be addressed: Lesya N. Gumenyuk
Bulvar Lenina, 5/7, Simferopol, 295006, Republic of Crimea; ur.liam@kuynemyg_aysel

About paper

Author contribution: Soldatenko AA — study concept and design, data acquisition; Gumenyuk LN — data analysis and interpretation, manuscript writing; Berdieva DM — data acquisition; Ponomarchuk EI — data analysis and interpretation.

Compliance with ethical standards: the study was approved by the Ethics Committee of the S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University (protocol No. 10 dated 16 October 2021), planned and conducted in accordance with the Declaration of Helsinki. The informed consent was submitted by all individuals included in the study.

Received: 2024-07-02 Accepted: 2024-07-21 Published online: 2024-08-27
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Table 1. Characteristics of patients with PCAS
Note: AFS — average final score.
Table 2. Dynamic changes in the plasma TNFα, IL1β, IL6 levels during treatment of patients with PCAS (median [25%; 75%])
Note: р — significance of differences between the groups compared, Δ — difference of changes.
Table 3. Dynamic changes in the mental status parameters during treatment of patients with PCAS
Note: AFS — average final score, Δ — difference of changes.