Funding: this research was funded by the grant №075-15-2019-1789 from the Ministry of Science and Higher Education of the Russian Federation allocated to the Center for Precision Genome Editing and Genetic Technologies for Biomedicine.

Author contribution: Shmitko AO — study planning, data collection, writing Original Draft Preparation; Bulusheva IA — methodology, data analysis, writing Original Draft Preparation; Vasiliadis IA, Suchalko ON, Syrko DS — data analysis, software, visualization; Belova VA — study planning, manuscript review and editing; Pavlova AS — data curation, data analysis, software; Korostin DO — conceptualization, supervision, methodology, manuscript review and editing.