ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2024 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Dynamic changes of inflammatory markers in the early stages of chronic kidney disease in patients with type 1 diabetes mellitus
About authors
1 South-Ural State Medical University, Chelyabinsk, Russia
2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia
3 Peoples' Friendship University of Russia, Moscow, Russia
Correspondence should be addressed: Lyudmila Yu. Zhuravleva
Vorovsky, 70 (Medgorodok), korp. 8, 454048, Chelyabinsk, Russia; ur.iam@0161_analim
About paper
Author contribution: Osikov MV, Efros LA — study planning, developing the study concept and design, literature review, data interpretation, manuscript draft writing; Zhuravleva LYu — data acquisition, statistical processing, and interpretation, manuscript writing; Fedosov AA — literature review, data interpretation, manuscript writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 5 dated 10 June 2024) and conducted in accordance with Good Clinical Practice and the principles of the Declaration of Helsinki.
Received: 2024-10-24
Accepted: 2024-11-25
Published online: 2024-12-23
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Table 1. Clinical characteristics and comparative analysis of the groups of patients with T1D having and not having CKD (n = 159)
Note: * — significant intergroup differences (p < 0.05). Categorical indicators were compared using the Pearson’s chi-squared test (χ2), Mann–Whitney U test was used in other cases.
Table 2. Albuminuria indicators in patients with T1D and CKD, abs. (%)
Note : * — significant intergroup differences (p < 0.05). Categorical indicators were compared using the Pearson’s chi-squared test (χ2).
Table 3. eGFR (mL/min/1.73 m2) in patients with T1D and CKD, Ме [Q1; Q3]
Note: Mann–Whitney U test was used to compare the values.
Table 4. Inflammatory markers in patients with T1D and CKD, Ме [Q1; Q3]
Note: Mann–Whitney U test was used to compare the values.
Table 5. Markers, acute phase reactants, in patients with T1D and CKD, Ме [Q1; Q3]
Note: Mann–Whitney U test was used to compare the values.
Table 6. Correlation between eGFR (mL/min/1.73 m2) and inflammatory markers in patients with T1D and CKD
Note: Spearman’s rank correlation coefficients (R) are provided.
