2025 / 01

Next Paper
DOI: 10.24075/brsmu.2025.008
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Predictive model for mortality in patients with abdominal sepsis

Osikov MV1,3, Telesheva LF1, Konashov AG1,2, Konashov VA1,2, Gusev AV1,3, Boyko MS1
About authors

1 South Ural State Medical University, Chelyabinsk, Russia

2 City Clinical Hospital No. 8, Chelyabinsk, Russia

3 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia

Correspondence should be addressed: Mikhail V. Osikov
ur.xednay@vokiso.forp

About paper

Author contribution: Osikov MV, Telesheva LF, Konashov AG — study concept and design; Konashov VA, Konashov AG, Gusev AV, Boyko MS — data acquisition and processing; Konashov VA, Konashov AG — manuscript writing; Osikov MV — editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 10 dated 02 November 2023).

Received: 2025-01-31 Accepted: 2025-02-14 Published online: 2025-02-23
|
  1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus defnitions for sepsis and septic shock (Sepsis-3): JAMA. 2016; 315 (8): 801–10. DOI: 10.1001/jama.2016.0287.
  2. Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020; 46 (8): 1552–62. DOI: 10.1007/s00134-020-06151-x.
  3. Font MD, Thyagarajan B, Khanna AK. Sepsis and Septic Shock — Basics of diagnosis, pathophysiology and clinical decision making. Medical Clinics of North America. 2020; 104 (4): 573–85. DOI: 10.1016/j.mcna.2020.02.011.
  4. Peksöz R, Ağırman E, Şentürk F, Albayrak Y, Atamanalp SS. A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review. Eurasian J Med. 2022; 54 (Suppl1): 66–70. DOI: 10.5152/eurasianjmed.2022.22296.
  5. Sartelli M, Abu-Zidan FM, Catena F, et al. Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study). World J Emerg Surg. 2015; 10 (61). DOI: 10.1186/s13017-015-0055-0.
  6. Sartelli M, Abu-Zidan FM, Labricciosa FM, et al. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study. World J Emerg Surg. 2019; 14 (34). DOI: 10.1186/s13017-019-0253-2.
  7. Fan Z, Jiang J, Xiao C, Chen Y, Xia Q, Wang J, et al. Construction and validation of prognostic models in critically Ill patients with sepsis-associated acute kidney injury: interpretable machine learning approach. J Transl Med. 2023; 21 (1): 406. DOI: 10.1186/s12967-023-04205-4.
  8. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996; 22 (7): 707–10. DOI: 10.1007/BF01709751. PMID: 8844239.
  9. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985; 13 (10): 818–29. PMID: 3928249.
  10. Iba T, Nisio MD, Levy JH, Kitamura N, Thachil J. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open. 2017; 7 (9): e017046. DOI: 10.1136/bmjopen-2017-017046.
  11. Kal'kuljator prognoza letal'nosti pri abdominal'nom sepsise: svidetel'stvo o gosudarstvennoj registracii programm dlja JeVM No 2024686256 Rossijskaja Federacija. M. V. Osikov, L. F. Telesheva, A. G. Konashov, A. V. Gusev, V. A. Konashov — No 2024685640; zajavl. 30.10.24; opubl. 06.11.24. Russian
  12. Dronamraju S, Agrawal S, Kumar S, Acharya S, Gaidhane S, Wanjari A, et al. Comparison of PIRO, APACHE IV, and SOFA Scores in Predicting Outcome in Patients with Sepsis Admitted to Intensive Care Unit: A Two-year Cross-sectional Study at Rural Teaching Hospital. Indian J Crit Care Med. 2022; 26 (10): 1099– 105. DOI: 10.5005/jp-journals-10071-24323.
  13. Wiersinga WJ, van der Poll T. Immunopathophysiology of human sepsis. EBioMedicine. 2022; 86: 104363. DOI: 10.1016/j.ebiom.2022.104363
  14. Strelcova EI, Peshkova IV, Samatov IJu, Valeeva VA, Vereshhagin EI. Limfopenija kak faktor, opredeljajushhij tjazhest' sepsisa, kak tochnyj kriterij diagnostiki i kak ob#ekt terapii. Journal of Siberian Medical Sciences. 2020; (3): 108–25. Russian.
  15. Hany A Zaki, Soumaya Bensliman, Khalid Bashir, et al. Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and metaanalysis. Syst Rev. 2024; 13: 37. DOI: 10.1186/s13643-023-02432-w.
  16. Plebani M. Why C-reactive protein is one of the most requested tests in clinical laboratories? Clin Chem Lab Med. 2023; 61 (9): 1540–5. DOI: 10.1515/cclm-2023-0086.
  17. El Shabrawy RM, Gawish A, Elgabry R, Nasr FM, Diab M, Gamal D. Presepsin, procalcitonin and C reactive protein as diagnostic biomarkers of sepsis in intensive care unit patients. Microbes and Infectious Diseases. 2021; 2. DOI: 10.21608/mid.2021.54196.1100.
  18. Huang N, Chen J, Wei Y, Liu Y, Yuan K, Chen J, et al. Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study. BMC Infect Dis. 2022; 22 (1): 662. DOI: 10.1186/s12879-022-07650-6.
  19. Balkrishna A, Sinha S, Kumar A, Arya V, Gautam AK, Valis M, Kuca K, Kumar D, Amarowicz R. Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management. Biomed Pharmacother. 2023; 165: 115183. DOI: 10.1016/j.biopha.2023.115183.
  20. Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet. 2019; 394: 1949–64. DOI: 10.1016/S0140-6736(19)32563-2.
  21. Peerapornratana S, Manrique-Caballero CL, Gómez H, Kellum JA. Acute kidney injury from sepsis: Current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019; 96: 1083–99. DOI: 10.1016/j.kint.2019.05.026.
  22. Marín Oyarzún CP, Glembotsky AC, Goette NP, Lev PR, De Luca G, Baroni Pietto MC, et al. Platelet Toll-Like Receptors Mediate Thromboinflammatory Responses in Patients With Essential Thrombocythemia. Front Immunol. 2020; 11: 705. DOI: 10.3389/fimmu.2020.00705.
  23. Pravin Patel, James V. Michael, Ulhas P. Naik, Steven E. McKenzie. Platelet FcgRIIA in immunity and thrombosis: adaptive immunothrombosis. J Thromb Haemost. 2021; 19: 1149–60. DOI: 10.1111/jth.15265.
  24. Tsantes AG, Parastatidou S, Tsantes EA, Bonova E, Tsante KA, Mantzios PG, et al. Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Life (Basel). 2023; 13 (2): 350. DOI: 10.3390/life13020350.
  25. Giustozzi M, Ehrlinder H, Bongiovanni D, Borovac JA, Guerreiro RA, Gąsecka A, et al. Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment. Blood Rev. 2021; 50: 100864. DOI: 10.1016/j.blre.2021.100864.
  26. Sijia Liu, Ting Yang, Qingsong Jiang, et al. Lactate and Lactylation in Sepsis: A Comprehensive Review. J Inflamm Res. 2024; 17: 4405–4417. DOI: 10.2147/JIR.S459185.
  27. Rui Yin, Xiaoshan Yang, Yanfen Yao. Risk factors for acute respiratory distress syndrome in sepsis patients: A meta-analysis. Heliyon. 2024; 10 (18): e37336. DOI: 10.1016/j.heliyon.2024.e37336.
  28. Sanjana Chetana Shanmukhappa, Srivatsa Lokeshwaran. Affiliations expand. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. PMID: 33232065 Bookshelf ID: NBK564395.