2025 / 04

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DOI: 10.24075/brsmu.2025.039
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Brain natriuretic peptide and corticosterone dynamics in experimental chronic heart failure during physical activity

Dzhandarova TI1, Tabunshchikova MO2, Kubanov SI1, Domenyuk DA2
About authors

1 North Caucasus Federal University, Stavropol, Russia

2 Stavropol State Medical University, Stavropol, Russia

Correspondence should be addressed: Tamara I. Dzhandarova
proezd Molodezhnyj, 17, Stavropol, Russia; ur.xednay@avoradnajd

About paper

Author contribution: Dzhandarova TI — experimental design and procedure, material resources, editing and data analysis; Tabunshchikova MO — animal handling and enzyme-linked immunoassay, statistical processing and data analysis; Kubanov SI — design and data analysis; Domenyuk DA — material resources for the study.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Stavropol State Medical University (protocol No. 100 dated 17 June 2021) and conducted in accordance with the requirements of the Order of the Ministry of Health of the Russian Federation No. 708n of 23.08.2010 “On approval of principles of laboratory practice”, Orders of the Ministry of Health of the USSR No. 742 of 13.11.1984 “On approval of the experimental animal handling principles” and No. 48 of 23.01.1985 “On regulation of the use of experimental animals”.

Received: 2025-08-07 Accepted: 2025-08-21 Published online: 2025-08-23
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Fig. 1. Serum concentration of brain natriuretic peptide in 6-month-old rats
Fig. 2. Serum concentration of corticosteroids in 6-month-old rats
Fig. 3. Serum concentration of brain natriuretic peptide in 19-month-old rats
Fig. 4. Serum concentration of corticosteroids in 19-month-old rats