ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Susceptibility of the nontuberculous mycobacteria circulating in Russia to bedaquiline
About authors
1 Central Tuberculosis Research Institute, Moscow, Russia
2 Russian University of Medicine, Moscow, Russia
Correspondence should be addressed: Tatiana G. Smirnova
Yauzskaya alleya, 2, str. 1А, Moscow, 107564, Russia; ur.liam@aktat_s
About paper
Funding: the study was conducted under the State Assignment of the Central Tuberculosis Research Institute, R&D project: 123061500080-6 “Developing an Import-Independent Technology to Determine Minimal Inhibitory Concentrations of Antibacterial Drugs Effective Against the Clinically Significant Nontuberculous Mycobacterial Species”
Author contribution: Chernousova LN, Ergeshov AЕ — study design; Ustinova VV, Kiseleva EA — experimental procedure; Smirnova TG — data analysis, manuscript writing; Larionova EE — data analysis; Zaytseva AS — literature review, manuscript draft writing; Andreevskaya SN — data analysis; all authors contributed to the discussion.
Compliance with ethical standards: the study was conducted in accordance with the principles of the Declaration of Helsinki (1964) and its further revisions.
Received: 2025-10-02
Accepted: 2025-10-18
Published online: 2025-10-30
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Fig. Bedaquiline MIC distribution for the studied slow-growing NTM species showing differences in drug susceptibility. MAC — M. avium complex mycobacteria (M. avium, M. intracellulare, M. chimaera); the resulting MIC value for the slow-growing NTM species showing high drug susceptibility (MAC and M. kansasii) are highlighted in green; MIC of M. xenopi, the slow-growing NTM species showing low bedaquiline susceptibility, is highlighted in red. The tentative ECOFF value is pointed by arrow
Table. Bedaquiline MIC for the studied NTM species
