2025 / 06

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DOI: 10.24075/brsmu.2025.071
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Characteristics of systemic inflammation in patients with endometritis-associated infertility

Savelieva OE , Krivolesova TA , Zhigalina AS , Sigareva LP , Saburov AV , Reznik VA
About authors

Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia

Correspondence should be addressed: Olga E. Savelieva
Litovskaya, 2, Saint Petersburg, 194100, Russia; ur.liam@anihcehc_aglo

About paper

Funding: the work was supported by the Russian Science Foundation grant 24-25-00244.

Author contribution: OE Savelieva — study design, analysis and interpretation of results, article authoring; TA Krivolesova — selection of patients, registration of results, article authoring; AS Zhigalina — data collection and analysis, article authoring; LP Sigareva — literature analysis, statistical processing of results; AV Saburov — selection of patients, registration of results; VA Reznik — research planning and supervision, article editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of St. Petersburg State Medical University (Minutes No. 18/07 of October 27, 2022), conducted in accordance with the federal laws of the Russian Federation (No. 152, 323, etc.) and Declaration of Helsinki 1964, with all subsequent additions and amendments regulating scientific research on biomaterials obtained from humans. All participants signed an informed consent form before participating in the study.

Received: 2025-10-29 Accepted: 2025-12-03 Published online: 2025-12-15
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  1. Klinicheskie rekomendacii. Vospalitel`ny`e bolezni zhenskix tazovy`x organov. 2024-2025-2026 (24.09.2024). Utverzhdeny` Minzdravom RF. 28 s. Russian.
  2. Singh N, Sethi A. Endometritis — Diagnosis,Treatment and its impact on fertility — A Scoping Review. JBRA Assisted Reproduction. 2022; 26 (3): 538–46.
  3. Kolmyk VA, Nasyrov RA, Kutusheva GF, Petrov VV, Grigoryev SG. Immunohistochemical value to treat patients with chronic endometritis. Pediatrician (St Petersburg), 2016; 7 (3): 17–22. Russian.
  4. Sukhanov AA, Dikke GB, Kukarskaya II. Epidemiology of female infertility and the experience of recovery of reproductive function in patients with chronic endometritis in the tyumen region. Russian Journal of Human Reproduction. 2023; 29 (3): 98–07. Russian.
  5. Konoplya AA, Gavrish SA, Konoplya AI, Loktionov AL. The application of intravascular laser irradiation of blood for the correction of the immune disturbances in patients presenting with chronic endometritis. Problems of Balneology, Physiotherapy and Exercise Therapy. 2016; 93 (5): 19–22. Russian.
  6. Trunova LA, Trunov AN, Marinkin IO, Kuleshov VM, Obuxova OO, Gorbenko OM i dr. Disbalans citokinov i aktivnost` immunovospalitel`nogo processa u zhenshhin s besplodiem. Allergologiya i immunologiya. 2014; 15 (1): 22–25. Russian.
  7. Kimura F, Takebayashi A, Ishida M, Nakamura A, Kitazawa J, Morimuneet A, et al. Review: Chronic endometritis and its effect on reproduction. J Obstet Gynaecol Res. 2019; 45 (5): 951–60.
  8. Ivanov DO, Krivolesova TA, Sigareva LP, Reznik VA, Savelieva OE. Prognostic potential of hematological inflammatory indexes for in vitro fertilization. Pediatrician (St. Petersburg). 2025; 16 (1): 88– 99. Russian.
  9. Shibutani M, Maeda K, Nagahara H, Noda E, Ohtani H, Nishiguchi Y, et al. A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer. Anticancer Res. 2013; 33: 3291–4.
  10. Yodying H, Matsuda A, Miyashita M, Matsumoto S, Sakurazawa N, Yamada M, et al. Prognostic Significance of Neutrophil-to- Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis. Ann Surg Oncol. 2016; 23: 646–54.
  11. Naess A, Nilssen SS, Mo R, Eide GE, Sjursen H. Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever. Infection. 2017; 45 (3): 299–307.
  12. Xu T, Zhang S-M, Wu H-M, Wen X-M, Qiu D-Q, et al. Prognostic significance of prognostic nutritional index and systemic immune-inflammation index in patients after curative breast cancer resection: a retrospective cohort study. BMC Cancer. 2022; 22 (1): 1128.
  13. Mishra K, Wadhwa N, Guleria K, Agarwal S. ER, PR and Ki-67 expression status in granulomatous and chronic non-specific endometritis. J Obstet Gynaecol Res. 2008; 34(3): 371–378.
  14. Savelieva OE, Krivolesova TA, Sigareva LP, Shlyakhova AD, Gurina OP, Reznik VA. Local and systemic immune status of women with infertility associated with chronic endometritis. Pediatrician (St. Petersburg). 2025; 16 (2): 56–65. Russian.
  15. Topolyanskaya SV, Eliseeva TA, Turna OI, Vakulenko ON, Bubman LI, Romanova MA, et al. Hematological indices — a possible marker of subclinical inflammation in very elderly patients and centenarians. Clinical review for general practice. 2022; 6: 6–13. Russian.
  16. Shibutani M, Maeda K, Nagahara H, Fukuoka T, Matsutani S, Kimura K, et al. The prognostic significance of the advanced lung cancer inflammation index in patients with unresectable metastatic colorectal cancer: A retrospective study. BMC Cancer. 2019; 19: 241.
  17. Gorbunova AP, Rukavishnikov GV, Kasyanov ED, Mazo GE. The role of hematological coefficients of systemic inflammation in the diagnosis and risk assessment of affective disorders. V. M. Bekhterev Review of psychiatry and medical psychology. 2024; 58 (1): 47–55. Russian.
  18. Manzyuk AV, Morozova TE, Gertsog AA, Litvinova MA. The prognostic value of hematological indices in systemic inflammatory diseases of connective tissue. Meditsinskiy sovet. 2024; 12: 136– 42. Russian.
  19. Lowsby R, Gomes C, Jarman I, Lisboa P, Nee PA, Vardhan M, et al. Neutrophil to lymphocyte count ratio as an early indicator of blood stream infection in the emergency department. Emerg Med J. 2015; 32: 531–4.
  20. Dalton HJ, Armaiz-Pena G, Gonzalez-Villasana V, Lopez- Berestein G, Bar-Eli M, Sood AK. Monocyte Subpopulations in Angiogenesis. Cancer Res. 2014; 74 (5): 1287–93.
  21. Titov LP. Monocytes, macrophages, dendritic and myeloid suppressor cells: genesis, classification, immunobiological properties. Proceedings of the National Academy of Sciences of Belarus, Medical series. 2018; 15 (3): 363–82.