2025 / 06

Next Paper
DOI: 10.24075/brsmu.2025.058
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

CLINICAL CASE

Severe acute α-PVP poisoning complicated by systemic rhabdomyolysis syndrome: case report

Makarovskaya NP1,2 , Lodyagin AN1,2,3 , Batocyrenov ChB4 , Razamasova SYu3 , Antonova AM1 , Narzikulov RA1 , Sokolova ES1
About authors

1 Dzhanelidze Research Institute of Emergency Care, Saint Petersburg, Russia

2 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia

3 Mechnikov North-Western State Medical University, Saint Petersburg, Russia

4 Golikov Research Center of Toxicology, Saint Petersburg, Russia

Correspondence should be addressed: Alexej N. Lodyagin
Budapeshtskaya, 3, Saint Petersburg, 192242, Russia; ur.liam@nigaydola

About paper

Author contribution: Makarovskaya NP — study concept and design, manuscript writing, data acquisition and processing; Batocyrenov ChB, Razamasova SYu, Narzikulov RA, Sokolova ES — data acquisition and processing; Lodyagin AN — editing; Antonova AM — X-ray data description.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Pavlov First Saint Petersburg State Medical University (protocol No. 277 dated 23 October 2023).

Received: 2025-10-02 Accepted: 2025-11-12 Published online: 2025-11-19
|
  1. Sinenchenko AG, Lodyagin AN, SHilov VV, Batocyrenov BV, Balabanova OL, SHikalova IA. Analiz struktury ostryh otravlenij sovremennymi psihoaktivnymi veshchestvami. Gigiena i sanitariya, 2020; (6): 569–74. Russian.
  2. Wander A. α-Pyrrolidinovalerophenones; British Patent 403 GB927475; Bern, Switzerland; 1963.
  3. European Monitoring Centre for Drugs and Drug Addiction. EMCDDA-Europol. Risk Assessment Report on 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one (α-Pyrrolidinovalerophenone, α-PVP); 2016. Available from: http://www.emcdda.europa.eu/system/files/publications/2934/TDAK16001ENN.pdf [Data obrashcheniya: 10 iyulya 2024].
  4. Zawilska JB, Wojcieszak J. α-Pyrrolidinophenones: a new wave of designer cathinones. Forensic Toxicology. 2017; 35: 201–16.
  5. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2012; 2 (1): 1–138.
  6. Makarovskaya NP, Lodyagin AN, Batocyrenov BV, Balabanova OL, Evdokimova EA. Ostrye otravleniya katinonami: epidemiologiya, patogenez, klinicheskaya kartina, diagnostika i principy lecheniya (obzor literatury). Toksikologicheskij vestnik. 2025; 1: 39–49. DOI: 10.47470/0869-7922-2025-33-1-39-49. Russian.
  7. Amanollahi A, Babeveynezhad T, Sedighi M, et al. Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis. Scientific Reports. 2023; 13: 17693. DOI: 10.1038/s41598-023-45031-4.
  8. Torres PA, Helmstetter JA, Kaye AM, Kaye AD. Rhabdomyolysis: pathogenesis, diagnosis, and treatment. Ochsner Journal. 2015; 15: 58–69.
  9. Cervellin G, Comelli I, Lippi G. Rhabdomyolysis: historical background, clinical, diagnostic and therapeutic features. Clinical Chemistry and Laboratory Medicine. 2010; 48: 749–56.
  10. Talaie H, Shahrokhian S, Malekpour F, Azizi F, Ghanei M. Rhabdomyolysis among acute human poisoning cases. Human & Experimental Toxicology. 2007; 26: 557–61.
  11. Richards JR, Bretz SW, Johnson EB, Turnipseed SD, Brofeldt BT, Derlet RW. Methamphetamine abuse and emergency department utilization. Western Journal of Medicine. 1999; 170: 198–202.
  12. Lodyagin AN, Batocyrenov BV, Narzikulov RA, i dr. Ostroe tyazhyoloe otravlenie opioidnym narkoticheskim veshchestvom metadonom, oslozhnyonnoe razvitiem sindroma dlitel'nogo sdavleniya (klinicheskij sluchaj). Zhurnal neotlozhnoj hirurgii imeni I. I. Dzhanelidze. 2024; 1 (14): 119–25. Russian.
  13. Tepaev RF, Lastovka VA, Pytal AV, i dr. Metabolicheskij acidoz: diagnostika i lechenie. Pediatricheskaya farmakologiya. 2016; 13 (4): 384–89. Russian.
  14. Livanov GA, Lodyagin AN, Razina AA, Glushkov SI, Ivanova AA, Volchkova EV, Batocyrenov BV. Blagopriyatnyj iskhod ostrogo tyazhelogo otravleniya metadonom (klinicheskoe nablyudenie). Obshchaya reanimatologiya. 2018; 14 (5): 25–31. Russian.