ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
CLINICAL CASE
Severe acute α-PVP poisoning complicated by systemic rhabdomyolysis syndrome: case report
About authors
1 Dzhanelidze Research Institute of Emergency Care, Saint Petersburg, Russia
2 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia
3 Mechnikov North-Western State Medical University, Saint Petersburg, Russia
4 Golikov Research Center of Toxicology, Saint Petersburg, Russia
Correspondence should be addressed: Alexej N. Lodyagin
Budapeshtskaya, 3, Saint Petersburg, 192242, Russia; ur.liam@nigaydola
About paper
Author contribution: Makarovskaya NP — study concept and design, manuscript writing, data acquisition and processing; Batocyrenov ChB, Razamasova SYu, Narzikulov RA, Sokolova ES — data acquisition and processing; Lodyagin AN — editing; Antonova AM — X-ray data description.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Pavlov First Saint Petersburg State Medical University (protocol No. 277 dated 23 October 2023).
Received: 2025-10-02
Accepted: 2025-11-12
Published online: 2025-11-19
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Today, acute poisoning with modern psychoactive substances and narcotic drugs is among the major causes of emergency admissions to toxicology units. There is a clear upward trend in the number of life-threatening complications of poisoning with psychoactive substances, one of which is rhabdomyolysis. Here we report a clinical case of severe acute α-PVP poisoning complicated by systemic rhabdomyolysis, describe the features of the clinical course and intensive care for this disorder. The early diagnosis, timely and effective treatment by conducting aggressive detoxification infusion therapy made it possible to prevent progression to the anuric phase of acute kidney injury, as well as to avoid invasive procedures of extracorporeal detoxification methods and probably avoid the adverse outcome of the acute α-PVP poisoning complicated by systemic rhabdomyolysis.