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ORIGINAL RESEARCH
Oral fluid changes in xerostomia patients on medications: clinical and laboratory characteristics
North Ossetian State Medical Academy, Vladikavkaz, Russia
Correspondence should be addressed: Soslan Kazbekovich Khetagurov
Pushkinskaya, 40, Vladikavkaz, 362019, North Ossetia–Alania, Russia; ur.xednay@888853psa
Author contribution: Khetagurov SK — concept and design of the study, supervision, manuscript editing; Sadaeva AA, Shovkhalova RU, Murzabekov BI — collection of clinical material, patient survey, manuscript authoring; Betersultanova DI, Oleinik II — oral health examination, sialometry, and compilation of the primary database; Dovletmurzaev ZS, Ozkan Zh-M, Sugaipova DA — laboratory tests, statistical processing of results, manuscript formalization.
Compliance with ethical standards: the study was approved by the local Ethics Committee of North Ossetian State Medical Academy of the Ministry of Health of the Russian Federation (Minutes No. 5 of September 20, 2025). All participants have voluntarily signed informed consent forms. The study did not involve animal experiments.
- Afanas'ev VV, Mirzakulova GF. Rotovaya zhidkost' i ee diagnosticheskoe znachenie: uchebnoe posobie. M.: Medicina, 2022; 120 s. Russian.
- Dawes C, Pedersen AML, Villa A, Ekstrom J, Proctor GB, Vissink A, et al. The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol. 2015; 60 (6): 863–74.
- Volosova MA, Petrova EN, Zaharov AV. Kserostomiya: klinicheskoe znachenie i podhody k diagnostike v terapevticheskoj stomatologii. Rossijskij stomatologicheskij zhurnal. 2020; 23 (4): 45–52. Russian.
- Sreebny LM, Valdini A. Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol. 1988; 66 (4): 451–8.
- Plemons JM, Al-Hashimi I, Marek CL. Managing xerostomia and salivary gland hypofunction: executive summary of a report from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2014; 145 (8): 867–73.
- Villa A, Abati S. Risk factors and symptoms associated with xerostomia: a cross-sectional study. Aust Dent J. 2011; 56 (3): 290–5.
- Turner MD, Ship JA. Dry Mouth and Its Effects on the Oral Health of Elderly People. J Am Dent Assoc. 2007; 138 (Suppl 1): 15–20.
- Arakelyan MG, Kostina IA, Vorobeva OV. Medikamentoznaya kserostomiya: patogenez, klinika, principy terapii. Stomatologiya. 2020; 99 (2): 62–68. Russian.
- Antonova EA, Lebedeva NN. Vliyanie lekarstvennyh preparatov na slyunootdelenie i sostoyanie polosti rta u pacientov s hronicheskimi zabolevaniyami. Klinicheskaya stomatologiya. 2021; 1: 23–29. Russian.
- Polyakov IV, Reshetov IV. Sostoyanie slizistoj obolochki polosti rta u pacientov posle luchevoj terapii zlokachestvennyh opuholej golovy i shei. Onkostomatologiya. 2022; 2 (1): 15–22. Russian.
- Villa A, Wolff A, Aframian D, Vissink A, Ekstrom J, Proctor G, et al. World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment. Clin Oral Investig. 2015; 19 (7): 1563–80.
- Aliko A, Wolff A, Dawes C, Aframian D, Proctor G, Ekstrom J, et al. World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120 (2): 185–206.
- Wolff A, Joshi RK, Ekstrom J, Aframian D, Pedersen AML, Proctor G, et al. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: a systematic review sponsored by the World Workshop on Oral Medicine VI. Drugs R D. 2017; 17 (1): 1–28.
- Thomson WM, Chalmers JM, Spencer AJ, Williams SM. The Xerostomia Inventory: a multi-item approach to measuring dry mouth. Community Dent Health. 1999; 16 (1): 12–17.
- Thomson WM, Williams SM. Further testing of the Xerostomia Inventory. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89 (1): 46–50.
- Navazesh M. Methods for collecting saliva. Ann N Y Acad Sci. 1993; 694: 72–77.
- Gileva OS, Kuznecova LV, Smirnova NYu. Diagnostika i lechenie kserostomii v stomatologicheskoj praktike: rukovodstvo dlya vrachej. SPb.: SpecLit; 2023. 164 s. Russian.
- Thomson WM, Chalmers JM, Spencer AJ, Slade GD. Medication and dry mouth: findings from a cohort study of older people. J Public Health Dent. 2000; 60 (1): 12–20.