Acknowledgments: the authors thank V. N. Khayutin, General Director of the Harmony Medical Center (Yekaterinburg), for the opportunity to conduct the study at the center.

Author contribution: Zornikov DL — conceptualization, visualization, formal analysis, writing — manuscript preparation; Simarzina VM — laboratory investigations, interpretation of laboratory results, writing — review and editing; Islamidi DK — participant enrollment, formation of clinical groups, collection of biomaterial, anamnestic and clinical data, analysis and interpretation of clinical data, writing — review and editing; Belykh NS — participant enrollment, collection of biomaterial, anamnestic and clinical data; Kornilov DO — laboratory investigations, interpretation of laboratory results, writing — review and editing; Abakumova EI — participant enrollment, collection of anamnestic and clinical data; Khayutin LV — collection of anamnestic and clinical data, writing — review and editing; Plotko EE — project administration, writing — review and editing; Voroshilina ES — supervision, study design, data analysis and interpretation, writing — review and editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of Ural State Medical University (Protocol No. 1 dated January 24, 2020; Protocol No. 4 dated May 26, 2023). Informed consent was obtained from all study participants.