Funding: the article is based on the results obtained when implementing the Agreement on the provision of grants in the form of subsidies from the federal budget to support the creation and development of world-class research centers that conduct research and development in areas prioritized for scientific and technological advancement FZSM-2026-0005.

Author contribution: Sorokin VA — sample preparation, data acquisition and analysis, literature review, manuscript writing; Abdulkhakov SR — study planning, data analysis and interpretation; Shakirova GF — data acquisition and analysis, literature review; Odintsova AKh — data acquisition, clinical assessment and follow-up of patients; Abdulkhakov RA — study planning, data interpretation, manuscript editing; Grigorieva TV, Laikov AV — laboratory testing of biomaterials; Roumiantsev SA — study planning, general management, manuscript editing; Shestopalov AV — study planning, data analysis and interpretation, manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Pirogov Russian National Research Medical University (protocol No. 186 dated June 26, 2019).