ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Dopamine and serotonin metabolism in the striatum of the chronic parkinson's disease mouse model
About authors
1 National Research Centre "Kurchatov Institute", Moscow, Russia
2 Russian Сenter of Neurology and Neurosciences, Moscow, Russia
Correspondence should be addressed: Anelya Kh. Alieva
pl. Academika Kurchatova, 2, str. 1, 123182, Moscow, Russia; ur.xednay@gmi.ha-aveila
About paper
Funding: the study was conducted within the framework of performing the state task for the National Research Center "Kurchatov Institute" (topic 5F.5.9).
Author contribution: Rudenok MM — modeling, material collection, experimental data analysis, manuscript writing; Semenova EI, Rybolovlev IN, Partevian SA, Lukashevich MV — modeling, material collection; Abaimov DA — metabolite analysis, data acquisition; Slominsky PA, Shadrina MI, Alieva AKh — experimental concept, experimental data analysis, manuscript writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the National Research Center "Kurchatov Institute" (protocol No. 1 dated January 16, 2024) was strictly compliant with the ARRIVE 2.0 guidelines and 3R (Replacement, Reduction, Refinement) principles.
Received: 2026-07-30
Accepted: 2026-09-07
Published online: 2026-09-16
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Fig. 1. Schematic representation of the chronic PD model protocol
Fig. 2. Dynamic changes in the DA turnover compared to the control, %. The DA level and its metabolic coefficients in the control were taken as 100%
Table 1. Changes in the levels of DA, 5-HT and their metabolites in the striatum of mice with the chronic PD model
Note: * — average fold change of the indicator; * * — standard deviation. Significant results are highlighted in bold and # , p < 0.05.
Table 2. Dopamine and serotonin turnover in the striatum of mice with the chronic MPTP/probenecid — induced PD model, %
Note: * — Metabolic coefficients in the control were taken as 100%.
