Original research Synthesis, structure and biological activity of novel pentacoordinated zvitter-ionic complexes of silicon on the base of α-amino- and α-hydroxyacids
Nikolin AA, Krupina SI, Arkhipov DE, Kramarova EP, Korlyukov AA, Shkoporov AN, Shipov AG, Kafarskaya LI, Baukov YuI, Negrebetsky VV
Eight novel hypercoordinated silicon compounds were synthesized. Their structures were confirmed by multinuclear spectroscopy of nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction study. The prognosis of biological activity indicated that complexes of hypercoordinated silicon could be screened as cardioprotective agents, and drugs for side (lateral) amiotrophic sclerosis treatment based on these complexes could be developed. All studied compounds had low predicted toxicity, which was confirmed by cytotoxicity tests on the model of tissue and bacterial cultures.
Received: 2012-07-11
Published online: 2017-01-05
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VIEWS 4136
Original research Synthesis and antioxidative properties of some fullerene C60 derivatives
Ioutsi VA, Sokolov SA, Semivrazhskaya OO, Apenova MG, Belov NM, Kovalev SV, Shevchenko VE, Negrebetsky VV
Synthesis and investigation of the antioxidative properties of four new fullerene C60 derivatives are reported. Two new synthetic procedures of the fulleropyrrolidine derivatives preparation were developed. All structures were confirmed by means of nuclear magnetic resonance spectroscopy and infrared spectroscopy, mass-spectrometry with laser desorption/ionization and high-resolution mass-spectrometry. Antioxidative properties were investigated by determination of peroxide number using the standard procedure.
Received: 2012-05-23
Published online: 2017-01-05
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VIEWS 3890
Original research The influence of complex bacterial preparations on oxidant functions of polymorphonuclear leukocytes of donors’ blood
Usanova EA, Chausova SV, Filatov OYu, Krasyuk OV, Efimov BA, Balyakin YuV
In this article there was estimated a priming effect of Staphylococcus aureus and Klebsiella pneumoniae at the polymorphonuclear leukocytes by measuring luminal- and lucigenin amplified chemiluminescence of donors' blood. It was shown that bacterial antigens of both microorganisms stimulated oxidant functions of leukocytes.
Received: 2011-12-06
Published online: 2017-01-05
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VIEWS 4119
Original research Electron microscopic criteria for the congenital central core myopathy differential diagnostics in human
Shatalov PA, Sukhorukov VS, Kharlamov DA, Brydun AV, Glinkina VV, Vlodavets DV, Vinogradskaya IS, Suslov VB, Likhacheva LM
Various methods of muscle biopsy morphological analysis are very important in the differential diagnostics of congenital myopathies. Not all neuromuscular diseases are identified by clear diagnostic criteria of morphological changes. The aim of this study was to search for electron microscopic markers, effective for the differential diagnosis of central core myopathy. Muscle biopsies were investigated in 56 patients aged from 1 to 21 years with diagnosis of central core myopathy (24 patients), multicore disease (6 patients), sarcotubular myopathy (10 patients), mitochondrial myopathy (16 patients). There were used methods of light (including histochemical) and electron microscopy. There were revealed basic electron-microscopic characteristics that could be used for differential diagnosis of congenital myopathies: central core, multicore and sarcotubular myopathies, as well as their morphological differences from mitochondrial myopathies.
Received: 2012-06-15
Published online: 2017-01-05
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VIEWS 4005
Method Universal method of staining of the infl ammatory centers and the intact brain tissues in vibratomic and semithin sections
Dubrovin IP, Komissarova SV, Turygina SA
It is suggested a new method of brain tissue staining which contrasts cell parts like nucleus, cytoplasm, chromatin ultrastructure and the border of neuron cytoplasm, indistinguished by other methods. Equally with nervous tissue connective tissue is stained well also, blood vessels in particular. Macrophages become metachromatic. The proposed formular is universal and it is suitable for almost all objects of the study in the light microscope: paraffin, cryotomic, vibratomic and semithin sections.
Received: 2011-12-09
Published online: 2017-01-05
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VIEWS 3935
Original research Comparative analysis of heart rate variability in patients with a complicated and uncomplicated arterial hypertension
Golubeva GYu, Golubev YuYu, Melentiev AS
It was studied a comparative analysis of variability of cardiac rhythm in 105 patients with complicated and uncomplicated arterial hypertension. It was shown that in the majority of patients with stable course of arterial hypertension it was found a moderate reduction in the indices of heart rate variability, reflecting a relative increase of the tone of the sympathetic nervous system while preserving parasympathetic influences. The occurrence of hypertensive crises was associated with a significant decrease in all indices of heart rate variability, clear predominance of sympathetic activity and a sharp oppression inhibition of vagal effects on the cardiovascular system.
Received: 2012-06-29
Published online: 2017-01-05
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VIEWS 4074
Original research Multidetector computed tomography in the diagnosis of sclerosing mesenteritis
Yudin AL, Yumatova EA, Sologubova GF, Aliev MM
The multidetector computed tomography diagnosis results of sclerosing mesenteritis in 76 patients are presented. Typical signs of sclerosing mesenteritis are discussed and indices of diagnostic value are estimated. The main pattern ("fat ring" sign) achieves 100 % specificity and positive predictive value and 75 % sensitivity.  
Received: 2012-06-15
Published online: 2017-01-05
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VIEWS 4020
Original research Medical hemostasis in patients with gasrtoduodenal ulcer bleeding: state of the problem and real prospects
Schegolev AA, Mitichkin AE, Al Sabunchi OA, Valetov SA, Pavlychev AV, Klochneva EA
The aim of this study was to evaluate the efficacy of using intravenous form of proton pump inhibitors in treatment of patients with upper gastrointestinal bleeding. The study included 71 patients. 30 patients in the first group received parenteral antisecretory therapy with omeprazole and the second group of 41 patients received omeprazole in capsules. The study confirmed the effectiveness of medicamental hemostasis with the usage of intravenous proton pump inhibitors in patients of that group as a part of a combined therapy based on the method of endoscopic prevention of recurrent hemorrhage.
Received: 2012-07-13
Published online: 2017-01-05
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VIEWS 4000