Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

SCImago Journal & Country Rank

Log In Registration RU

Ivashchenko AV, Yablokov AE, Fedyaev IM, Tlustenko VP, Rotin NE, Tugushev VV

Accuracy is a common challenge in dental implant placement. A successful clinical outcome is largely determined by accurate positioning of the implant at the prepared site and proper angulation. This study aimed to compare the divergence between the axes of the implants installed using a classic freehand technique. Cartesian coordinates of implant necks were determined on the CT images of 34 patients in the XOY (horizontal) plane, followed by the coordinates of implant apices. The obtained data were submitted to the original software developed by the authors (patent 2018661716) that automatically computed an angle between the insertion axes of the installed implants. We found that in 87% of cases, this angle was significantly greater (up to 27°) than recommended by implantation dentistry guidelines (7°). In 100% of the studied cases, the implants were not parallel; in sector 1, the deviation was 27° 4`.

Received: 2018-10-26

Published online: 2019-04-15

DOI: 10.24075/brsmu.2019.027

Comments 0

VIEWS 3409

Petrukhina NB, Zorina OA, Shikh EV, Kartysheva EV, Kudryavtsev AV

In this paper, we propose a model for predicting the risk of severe chronic generalized periodontitis (GCP) in patients with metabolic syndrome based on the levels of tumor necrosis factor alpha (TNF-α) in the periodontal pocket exudate. The analysis of oral cavity cytokine profiles conducted in 537 patients with GCP and comorbid metabolic syndrome showed that increased TNF-α correlated with the severity of GCP: higher levels of TNF-α were observed in patients whose condition was more severe. The prognostic model built in Statistica. 10 allowed us to use TNF-α as a prognostic criterium for GCP severity. We determined the cut-off point above which a high risk of severe GCP can be concluded with 91.2% sensitivity and 70.8% specificity. The spreadsheet in Microsoft Exсel 2010 automatically computed the risk of severe GCP from a patient’s TNF-α concentrations in the PP, which makes the model convenient for routine clinical use in dentistry.

Received: 2018-09-24

Published online: 2019-04-14

DOI: 10.24075/brsmu.2019.026

Comments 0

VIEWS 3491

Tlustenko VP, Bayrikov IM, Trunin DA, Gusyakova OA, Komlev SS

An objective assessment of the morphofunctional characteristics of the state of soft tissues and bone structures adjacent to the dental implant allows to control the dynamics of the processes of osseointegration in the jaw-dental implant system. The aim of the work was to investigate the level of the β-CrossLaps, С-reactive protein (CRP), osteocalcin markers after orthopedic treatment of patients using dental implant supported advanced dental restoration technologies, to perform a biochemical analysis of the oral fluid of patients after restoration using dental implants and new two-part dental implants. In patients of the index group (52 people), the removable prostheses with metal frame and fixing elements or the commercially available dental implant supported removable prostheses were installed. For the patients of the control group (12 people), the commercially available dental implant supported removable prostheses of acrylic plastics were constructed. For all the patients after 6 months the level of β-CrossLaps, CRP, osteocalcin markers in the oral fluid was analysed. In patients of the index group, the average content of β-CrossLaps was 0.0126 ± 0.002 ng/ml, in the control group it was 0.0147 ± 0.002 ng/ml. The average content of the CRP in patients of the index group was 0.358 ± 0.019 mg/l, in patients of the control group it was 0.78 ± 0.01 mg/l. In patients of the index group, the average content of osteocalcin was 1.46 ± 0.25 ng/ml, in the control group it was 1.98 ± 0.31 ng/ml. It has been shown that biochemical markers of the oral fluid can be used to predict complications after the dental implants installation. Restoration with two-part dental implants of modern design is associated with fewer complications.

Received: 2018-11-27

Published online: 2019-04-13

DOI: 10.24075/brsmu.2019.025

Comments 0

VIEWS 3441

Gavryushin MYu, Sazonova OV, Gorbachev DO, Borodina LM, Frolova OV, Tupikova DS

The proportion of obese and overweight children is alarmingly high. This dictates the need for promoting healthy lifestyle and eating habits in children. Summer camps provide a wide range of activities to improve children’s health. However, methods used to assess children’s nutritional status during a camp session need to be analyzed in depth, and a rationale should be provided for the use of bioelectrical impedance analysis (BIA) and anthropometric measurements as efficacy criteria for summer camp healthcare. We examined 125 boys and 221 girls aged 8–15 years spending their summer holidays at 3 different camps. Measurements were taken twice: on days 1 and 2 upon arrival to a camp and 2 days before leaving for home. In each camp, both positive and negative health weight dynamics were observed. The overall weight dynamics in children from camps 1 and 2 were statistically insignificant (p = 0.415 and p = 0.585), in contrast to camp 3 where those changes were significant (p = 0.025). BIA revealed that less than 44.34% of children had gained skeletal muscle mass during their stay at the camp, whereas weight loss was associated with both decreased fat and skeletal muscle masses. BIA confirms the results of anthropometric measurements and also provides information about the diet offered to children and their level of physical activity. Therefore, the use of anthropometric measurements and BIA could be an informative method for assessing the efficacy of healthcare in summer camps.

Received: 2018-12-10

Published online: 2019-04-12

DOI: 10.24075/brsmu.2019.024

Comments 0

VIEWS 3321

Berihanova RR, Minenko IA

In perimenopausal women, the frequency of thyroid diseases and metabolic syndrome (MS) increases. In this work, the effect of non-drug correction programs for menopausal disorders on the structural and functional state of the thyroid gland in patients with MS was evaluated. For that, five groups of women (330 people total) aged 45–50 years with climacteric syndrome (CS) against the background of MS were examined. For the index group and the experimental groups the following was used: basic treatment, exercise therapy, drinking balneotherapy, additional oral intake of multivitamins and minerals, as well as physical therapy — vibrotherapy, chromotherapy, music therapy, aromatherapy, aeroionotherapy in various combinations. In the control group, only basic treatment was used. The levels of thyroid-stimulating hormone (TSH) and free thyroxine (free T4) in serum were determined, a sonographic study of the thyroid gland was performed. According to the study results, the use of correction programs using physical therapy methods improved the functioning parameters of the pituitary-thyroid system in the surveyed patients. In women with moderate-severity CS, the best results were obtained while simultaneously using all the mentioned above physiotherapy methods: during the transition period the TSH decreased by 6.5%, during the postmenopausal period — by 5.6%, the level of free T4 increased by 6.5% and 6,6% respectively (р < 0.05, applied to both parameters). It can be concluded that non-drug programs, including physical therapy, have a protective effect on the thyroid gland function. In case of moderate-severity climacteric syndrome, the program with simultaneous use of vibrotherapy, chromotherapy, music therapy, aromatherapy, aeroionotherapy has priority.

Received: 2018-10-16

Published online: 2019-04-11

DOI: 10.24075/brsmu.2019.023

Comments 0

VIEWS 3381

Ganin IP, Kosichenko EA, Sokolov AV, Ioannisyanc OM, Arefev IM, Basova AYa, Kaplan AYa

Brain-computer interface based on the P300 wave (P300 BCI) allows activating a given command according to the electroencephalogram (EEG) response to a predetermined relevant stimulus. The same algorithm enables detecting a subjectively important item (i.e., one triggering emotional response) in an environment even without actively drawing attention to it. Such systems allow assessing the personal significance of certain information, which can be used in the diagnostics of disorders of emotional perception or value system, e.g., eating disorders. This study aimed to investigate the EEG responses of anorexia nervosa patients (diagnosis F50.0, n = 12, age 11–16 years) to the stimuli with different perceived emotional significance, as well as to validate application of P300 BCI to detect the focus of attention to subjectively important stimuli. The inclusion criteria were: diagnosed anorexia nervosa (diagnosis F50.0); active rehabilitation. We registered the EEG while presenting images with different content to the patients. The event-related potentials (ERP) were detected and analyzed with the help of MATLAB 7.1 (MathWorks; USA). Statistica 7.0 software (StatSoft; USA) was used for statistical analysis of the data. We have discovered that in passive viewing paradigm, images of body parts of emaciated people among other images caused ERP with higher amplitude than images of food. Moreover, the accuracy of detection was higher for images of body parts: 89% against 59%, respectively. Thus, we have proven the validity of applying P300 BCI to detect covert emotional foci of attention and added to the existing knowledge about the mechanisms of development of anorexia nervosa.

Received: 2018-10-08

Published online: 2019-04-10

DOI: 10.24075/brsmu.2019.022

Comments 0

VIEWS 3835

Morrison VV, Bozhedomov AYu

Burn injuries kill thousands of people. The aim of this study was to investigate the dynamics of systemic inflammatory response parameters, endothelial dysfunction markers and hemostasis impairment in patients with thermal burn injuries. The study was conducted in 51 patients aged 16 to 80 years presenting with moderate to severe thermal burns. The systemic inflammatory response was assessed based on the levels of tumor necrosis factor α (TNFα), a number of interleukins (IL6, IL12), the С-reactive protein, and the monocyte chemoattractant protein 1 (МСР-1). Hemostatic impairments were inferred from the results of coagulation tests that measured the activated partial thromboplastin time (APTT), the prothrombin index (PI), the prothrombin time (PT) and the platelet count. Endothelial dysfunction was analyzed based on the levels of vascular endothelial growth factor (VEGF), total endothelin (TE) and circulating endothelial cells. The dynamics of the listed parameters were studied over 45 days following the injury. Endothelial dysfunction markers peaked on days 3–15 (VEGF 828.9 ± 993.2 pg/mL, TE 3.0 ± 1.7 fmol/mL, CEC 6.4 ± 6.0 • 104/l, IL6 264.4 ± 131.2 pg/mL, TNFα 41.4 ± 111.9 pg/ml, C-reactive protein 128.3 ± 52.4 nmol/mL). Coagulation was significantly impaired during the same period (APTT 41.4 ± 17.7 s, PI 83.6 ± 15.4%, PT 22.3 ± 10.0 s). By day 30–35, blood concentrations of proinflammatory cytokines and inflammation mediators had declined (TNFα 3.9 ± 9.6 pg/mL, IL6 49.0 ± 35.9 pg/mL, С-reactive protein 81.9 ± 341 nmol/ml); in that phase, the coagulation potential was continuing to decrease (APTT 51.8 ± 34.1 s, PI 82.9 ± 19.4%, PT 24.9 ± 21.4 s). The study demonstrates that damage to the endothelium results from both injured tissue breakdown and inflammation mediators. The risk of thromboembolic and hemorrhagic complications is the highest on days 7 through 15 following thermal injury. Further research is needed to study the mechanisms of endothelial damage in patients with thermal burns.

Received: 2018-12-28

Published online: 2019-04-08

DOI: 10.24075/brsmu.2019.021

Comments 0

VIEWS 3306

Lychagin AV, Garkavi AV, Meshcheryakov VA, Kaykov VS

Osteoarthritis is a condition that mostly affects the elderly population and tends to be localized to the knee joint. At old age, active treatment options are limited by co-morbidities and a higher risk for surgical complications. Therefore, the search for strategies that could become a temporary alternative to knee replacement is a pressing concern. The aim of this study was to analyze how justifiable is total knee replacement in elderly patients with knee osteoarthritis and to propose a less aggressive therapeutic alternative to this surgery. The study included 178 patients over 60 years of age with clinically established knee osteoarthritis who had been previously recommended knee replacement but chosen not to undergo it. The choice of a treatment strategy tested in the study was based on the original grading scale for the evaluation of the knee joint dislocation syndrome. The treatment consisted of therapeutic arthroscopy and intraarticular injections of hyaluronic acid and platelet-rich plasma (PRP). The data were processed in Statistica 12. Data analysis revealed that 39.3% of the participants did not have compelling indications for knee replacement. The proposed combination therapy with intraarticular PRP injections and arthroscopy allowed all the patients to delay knee replacement for at least a year; unaided by arthroscopy, intraarticular injections worked well for only 40%.

Received: 2018-09-13

Published online: 2019-04-06

DOI: 10.24075/brsmu.2019.020

Comments 0

VIEWS 3485