Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

In this review of literature new tendencies in the questions of etiopathogenesis of ovarian cancer are highlighted. There are discussed some pathogenetic aspects in the progress of this pathology, such as proto-oncogenes and oncogenes. There are presented modern methods of screening and diagnostics of ovarian tumors. The opportunities of the application of biomarkers and their combinations for the early diagnostics of malignant ovarian neoplasms are discussed.

Received: 2014-10-07

Published online: 2017-01-05

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Dobrokhotova YuE, Grishin II, Ibragimova DM, Saprykina LV

The paper presents a method for the treatment of cervical pregnancy conducting a superselective embolization of the uterine arteries (leading to the cessation of blood flow along the branches of the uterine arteries supplying the cervical wall) by Embosphere microspheres 700–900 microns in size, and by HepaSphere microspheres 150–200 microns in size, as well as intra-arterial administration of methotrexate on one side in a dose of 25 mg and then vacuum aspiration of the ovum.

Received: 2014-10-07

Published online: 2017-01-05

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Nasyrova NI, Gallyamov EA, Ozolinya LA

The problem of correction of pelvic organ prolapse as well as its comorbid conditions are most actual problems in modern gynecology. Endoscopic procedures have been applied in this area and according to many authors this method provide rapid postoperative recovery and satisfactory results. We present the authors' own experience of laparoscopic sacrocolpopexy in combination with Burch colposuspension at the treatment of pelvic organ prolapse complicated with stress urinary incontinence.

Received: 2014-10-07

Published online: 2017-01-05

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Nasyrova NI, Gallyamov EA, Ozolinya LA, Gavrilov MV

Uterus myoma is the most common benign tumor of the female reproductive system. The most discussed method of treatment of this disease is a laparoscopic myomectomy. Along with recognized efficacy of the method, there are a number of difficulties associated with the problems of intraoperative blood loss and viability of sutures on the uterus. One of the effective solutions to the problems described above is the use of a temporary occlusion of the internal iliac arteries.

Received: 2014-10-07

Published online: 2017-01-05

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Saprykina LV, Dobrokhotova YuE, Filatova LA, Akimova LV, Saprykina OA, Ibragimova DM

The purpose of the study was to investigate the value of noninvasive and mini-invasive diagnostic methods of endometrial hyperplastic processes. 173 perimenopausal women were investigated. The accuracy of ultrasound investigation in case of endometrial pathology was 89.6%, sensitivity — 92.3 %, specificity — 64.71 %. The accuracy, sensitivity, specificity of Pipelle-biopsy was 93.9 %, 92.3 % and 100 %, respectively. Thus the ultrasound investigation can be used for early detection of endometrial pathology and should be accompanied by Pipelle-biopsy.

Received: 2014-10-07

Published online: 2017-01-05

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Filatova LA, Saprykina LV, Kheydar LA, Dobrokhotova YuE

The purpose of the investigation is to study the role of combined oral contraceptives (COCs) in the rehabilitation of patients after surgery for an ectopic pregnancy. 27 patients after surgery for the ectopic pregnancy were examined. The patients were divided into 2 groups. For the purpose of contraception and rehabilitation the patients of the 1st group received COC (30 meg ethinylestradiol and 150 meg desogestrel); the 2nd group did not receive it. There was observed a good control of the menstrual cycle, lack of intermenstrual bleeding in the patients of the 1st group. The indicated COC may be recommended after surgery for ectopic pregnancy.

Received: 2014-10-07

Published online: 2017-01-05

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Ozolinya LA, Lapina IA, Nesterova AO

Hemostatic balance is provided by complex interactions of the coagulation, fibrinolytic systems, platelets and vascular wall. R.Virhov's work, published in 1856, laid the foundation for the study of the problems of thrombosis and first substantiated its etiopathogenesis: slowing the rate of blood flow, changes in blood, vascular wall damage. Further development of the doctrine of thrombosis significantly changed the idea of the significance of each of these factors. The review describes the recent literature data on this issue.

Received: 2014-10-07

Published online: 2017-01-05

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Kruglikov GG, Suslov VB, Likhacheva LM, Stranzha NB, Oettinger AP

The use of preparations-prints of the organs, blood smears and films of connective tissue revealed exaggerated forms of ciliated and goblet cells in patients with allergies, phagocytic activity of macrophages in experimental pneumoconiosis, increase in the number of atypical red blood cells in patients with toxic anemia and hypoxia (experimental pneumoconiosis), the features of morphology of mast cells in the embryons of experimental animals.

Received: 2014-08-25

Published online: 2017-01-05

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