Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Pogodin PV, Lagunin AA, Ivanov SM, Konova VI, Filimonov DA, Poroykov VV

The purpose of the study is development of a specialized version of the computer system PASS — PASS Targets for computer-aided prediction of the spectra of interactions between chemical compounds and protein-targets based on ChEMBLdb database (14 version). Data on the interaction between 348 137 different compounds and protein-targets were extracted from ChEMBLdb and were used for PASS training. The average prediction accuracy calculated by leave-one-out cross-validation procedure is 98.1 %. The developed copputer system PASS Targets and be used to predict interaction with 3257 protein-targets representing eight major classes of protein-targets of 215 species.

Received: 2013-07-01

Published online: 2017-01-05

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VIEWS 3025

Dyakonova IN, Rakhmanova IV, Burmistrova DS, Ishanova YuS

In our research, using two electrophysiological methods (registration of auditory brainstem response, distortion product otoacoustic emission) we were estimating auditory function of immature rabbits in response of introduction of therapeutic doses of vancomycin (15 mg/kg daily, 7 days). Damaging action was reflected in a functional condition of peripheral department of the acoustic analyzer. According to the brainstem auditory evoked potentials it expressed in elevation of thresholds of the first peak of ABR and shortening of peripheral time of carrying out. According to distortion product otoacoustic emission — a decreased amplitude caused the acoustic answer to frequency of 4 kHz and change of speed of maturing of functioning of outer hair cells on frequencies of 2, 4, 6 kHz.

Received: 2013-09-23

Published online: 2017-01-05

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VIEWS 3307

Abstract has not been added yet...

Received: 2013-11-11

Published online: 2017-01-05

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VIEWS 3147

Lipatova VA, Botchey VM, Pistsova TV, Fedoseev VA, Klochkova AV, Belyakov VK, Sukhenko EP, Suslov VB, Vasilenko IA, Rumyantseva SA, Oettinger AP, Kutsev SI

There was conducted an electron microscopy of myocardial samples in mice after extended oral administration of gold nanoparticles with the aim of investigation of the effect of gold nanoparticles with a diameter of 2 nm to myocardial ultrastructure. It was shown that oral administration of gold nanoparticles even in the minimal tested dose (10 mg/ml) already at the early stages of the experiment (7 days) leads to a moderately pronounced cytotoxic effect with ultrastructural changes in all components of the myocardium. The severity of degenerative changes increased with the extension of the experiment, but the rough myocardial damage (necrosis) was not found at any time of the observation. There were described at unltractructural level changes in microcirculation, interstitium and cardiomyocytes, depending on the concentration of the administered drug and the phase of the experiment. Described degenerative changes in the myocardium caused by the introduction of gold nanoparticles can lead to morphological and functional failure of the heart.

Received: 2013-04-16

Published online: 2017-01-05

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VIEWS 3348

Alipov NN, Antonov IS, Alipova VN, Belyakova-Bodina AI, Kuznetsova TE, Sergeeva OV, Gordeev SA, Kovrov GV, Posokhov SI

The relationships between various heart rate variability indices and score values on the Wein autonomic state scale were studied in 32 students of 18–25 years old. No evident significant correlation was obtained between either of listed indices and score values. This calls into question the use of heart rate variability parameters in the quantitative estimation of systemic autonomic state as well as in identification of autonomic dysfunction and determination of its severity. These results also indicate that the general autonomic dysfunction is not always associated with the overexertion of the adaptation mechanisms.

Received: 2013-03-29

Published online: 2017-01-05

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VIEWS 3256

Sapozhnikov YaM, Minasyan VS, Mkhitaryan AS

On the basis of the examination of 264 children aged from 1 to 3 years after the acute otitis media, the survey algorithm was developed with the use of modern audiological and endoscopic equipment. It allows timely and accurately to determine the causes leading to the acute otitis media and hearing loss associated with the pathology of nasophariynx. It makes it possible to choose the optimum treatment regimen in each particular case, eliminating further development of persistent hearing loss and to minimize the need for bypass surgery of the tympanic cavity, and to ensure the harmonious speech development of a child.

Received: 2013-03-11

Published online: 2017-01-05

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VIEWS 3287

Bogomilsky MR, Radtsig EYu, Degtyareva DV

Objective methods of research are widely used for the diagnosis of various origins dysphonia. Over the last decades there has been a steady increase in the number of children with these conditions. Acoustic analysis provides the basic data for the evaluation of voice. This study can be used as a screening method to identify the pathology of the larynx. Acoustic voice analysis data are irreplaceable in the differential diagnosis of various diseases, as well as in monitoring the quality of the treatment.

Received: 2013-04-22

Published online: 2017-01-05

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VIEWS 3445

Adeishvili PS, Shamsheva OV, Polesko IV, Osipov GA

Mass spectrometry of microbial markers was used to study the microbial landscape of the oropharynx in 22 children with infectious mononucleosis aged from 3 to 14 years. The comparison group consisted of 10 children without clinical signs of infectious mononucleosis and acute respiratory viral infections including mucosal and tonsils hyperemia. The data obtained helped to verify and quantify the composition of the microbial community in the oropharynx in infectious mononucleosis and treat angina in infectious mononucleosis as a disease with the association of various opportunistic pathogens that exceeded the number of microbes in healthy children at least more than twice.

Received: 2013-03-20

Published online: 2017-01-05

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VIEWS 3165