Original research Association of the IL10 gene polymorphism with the development of persistent oligoarticular juvenile idiopathic arthritis
Nazarova LSh, Danilko KV, Malievsky VA, Viktorova TV
The aim of the study was to determine whether the IL10 –592C>A (rs1800872) polymorphism is associated with the development of persistent oligoarticular juvenile idiopathic arthritis (JIA) in children from Bashkortostan, Russia. Genotyping of 107 patients with persistent oligoarticular JIA and 206 healthy controls was performed by PCR-RFLP and real-time PCR methods. The IL10 –592CC genotype frequency was significantly higher in patients with persistent oligoarticular JIA than in controls (p = 0,033). After dividing the whole groups into subgroups based on gender there was found that the IL10 –592CC genotype and the IL10 –592C allele frequencies were significantly higher only in girls with persistent oligoarticular JIA in comparison to controls (p = 0,042 и p = 0,025, correspondingly). In this study we revealed the association of the IL10 –592C>A polymorphism with the development of persistent oligoarticular JIA in children from Bashkortostan, Russia.
Received: 2015-10-09
Published online: 2017-01-05
DOI:
Comments 0
VIEWS 4558
Original research High carrier frequency of CFTR gene mutations associated with cystic fibrosis, and PAH gene mutations associated with phenylketonuria in Russian population
Abramov DD, Kadochnikova VV, Yakimova EG, Belousova MV, Maerle AV, Sergeev IV, Ragimov AA, Donnikov AE, Trofimov DYu
Abstract has not been added yet...
Received: 2015-09-11
Published online: 2017-01-05
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Comments 0
VIEWS 4765
Original research Association between the activity of CYP2D6 enzyme and profile of efficacy and safety of haloperidol in patients with alcohol addiction
Sychev DA, Zastrozhin MS, Smirnov VV, Savchenko LM, Bryun EA, Guschina YuSh, Sorokin AS, Aguzarov AD
Abstract has not been added yet...
Received: 2015-10-06
Published online: 2017-01-05
DOI:
Comments 0
VIEWS 4648
Original research Reference ranges for standard coagulation tests and thrombodynamics assay during normal pregnancy at various gestational ages
Voroshilina ES, Ovsepyan RA, Plotko EE, Gerasimova OB, Baskova OYu, Budykina TS, Vuimo TA
Abstract has not been added yet...
Received: 2015-10-08
Published online: 2017-01-05
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Comments 0
VIEWS 4706
Original research Combining phases II and III in а clinical trial of “Hexasens”: assessment and reasoning
Ivanova-Radkevich VI, Machinskaya EA, Filonenko EV, Lukianets EA
Abstract has not been added yet...
Received: 2015-10-02
Published online: 2017-01-05
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Comments 0
VIEWS 4643
Method High sensitivity and high specificity inflammation detector
Titov VY, Kreynina MV, Petrov VA, Osipov AN, Kamchatnov PR, Shalina RI
Abstract has not been added yet...
Received: 2015-09-13
Published online: 2017-01-05
DOI:
Comments 0
VIEWS 4642
Method Biocompatible doxorubicin-loaded superparamagnetic iron oxide nanoparticles: synthesis and antineoplastic activity
Starostin KM, Olenin AYu, Fedotcheva TA, Shirokikh KE, Lisichkin GV, Shimanovskii NL
Abstract has not been added yet...
Received: 2015-09-16
Published online: 2017-01-05
DOI:
Comments 0
VIEWS 4527
Original research Trauma Doctors’ Medical and Legal Awareness of Emergency Medical Assistance (According to the Sociological Survey)
Lyadova MV, Tuchik ES, Lyadova AV
The article is devoted to the problem of trauma doctors' legal awareness of emergency medical assistance. Based on the results of sociological investigations, there were demonstrated the main causes of conflicts between doctors and patients and the ways to prevent them.
Received: 2015-02-17
Published online: 2017-01-05
DOI:
Comments 0
VIEWS 4310