The purpose of the work was studying of the autonomous nervous system's role in regulations of a liver's reactivity. Acute intoxication with carbon tetrachloride (CTC) in rats on the background of vagotomy served as a model. In those conditions the liver's reactive properties were investigated on the example of microvascular stream's and water metabolism's reorganization. With the help of morphological and biophysical methods it was revealed that CTC intoxication was accompanied by disturbances of liver's water metabolism which manifested in increasing of organ's total water saturation and decreasing of its structure extent. Morphological basis of those disturbances was dilatation of sinusoids and blood stasis in them, as well as hepatocytes' specific volume increasing. It was established, that the response of the liver to CTC toxicity in vagotomised rats was characterized by the lower degree of severity of changes in the water exchange in comparison with animals which were not performed vagotomy. That intensity was less in vagotomised rats' modification than in the initially intact animals. Peculiarities of the organ's structural reorganizations lay in the absence of deviations of such parameters as perimeter of sinusoids and nuclear-plazma ratio.