ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Intracellular pH as the Early Differential Marker of Glucocorticoid-Induced Apoptosis of Skin Fibroblasts
About authors
Department of Molecular Pharmacology and Radiobiology named after P. V. Sergeev, Medical-Biological Faculty, Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Aleksandr Duhanin
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.relbmar@30sad
Received: 2012-07-16
Accepted: 2012-12-19
Published online: 2017-01-05
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Early stages of dexamethasone-induced fibroplast apoptosis include changes in intracellular homeostasis determined by decreasing pH of the cytoplasm and increased intracellular calcium ion concentration. Na+/H+-transporter and plasma membrane calcium channels are molecular targets for the action of dexamethasone.
Keywords: apoptosis, intracellular pH, calcium, glucocorticoids, fibroblasts