ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2017 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Intracellular pH as the Early Differential Marker of Glucocorticoid-Induced Apoptosis of Skin Fibroblasts
About authors
Department of Molecular Pharmacology and Radiobiology named after P. V. Sergeev, Medical-Biological Faculty, Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Aleksandr Duhanin
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.relbmar@30sad
Received: 2012-07-16
Accepted: 2012-12-19
Published online: 2017-01-05
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Early stages of dexamethasone-induced fibroplast apoptosis include changes in intracellular homeostasis determined by decreasing pH of the cytoplasm and increased intracellular calcium ion concentration. Na+/H+-transporter and plasma membrane calcium channels are molecular targets for the action of dexamethasone.
Keywords: apoptosis, intracellular pH, calcium, glucocorticoids, fibroblasts