ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
REVIEW
Looking inside man: medical imaging
About authors
1 IzoMed Ltd., Moscow, Russia
2 Department of Positron Emission Tomography,
N. N. Blokhin Russian Cancer Research Center, Moscow, Russia
3 Department of Radiation and Cellular Oncology,
University of Chicago, Chicago, USA
4 Laboratory of the Structural Dynamics, Stability and Folding of Proteins,
Institute of Cytology of Russian Academy of Sciences, Saint-Petersburg, Russia
5 Department of Anatomy and Structural Biology,
Albert Einstein College of Medicine, New York, USA
6 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Elena Kulikova
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; moc.liamg@avokiluk.uy.anele
Received: 2016-08-15
Accepted: 2016-08-20
Published online: 2017-01-05
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Fig. 1. Non-Hodgkin lymphoma spread to the bone marrow. Computed tomography in the bone window (A) detects paravertebral tumor masses, but does not see lesion-infiltrated vertebrae, while magnetic resonance imaging (C) can detect these lesions (shown by arrows) confirmed by hybrid technologies: PET-CT (B) and 18F-fluorodeoxyglucose-enhanced PET-MRI (D). Thus, MRI is more sensitive in the diagnosis of bone marrow lesions and detects the first signs of bone destruction and plasma cell infiltrates before osteoclast hyperstimulation can be observed (Buchender et al. [24])
Fig. 2. Fabrication of blocks for targeted irradiation of a malignant tumor based on oxygen distribution in the tissue. (A) Slice of 3D image of pO2 levels in different regions of mouse fibrosarcoma; a projection of tumor area selected for irradiation is outlined in magenta. (B) Computer model of the irradiation block. (C) Irradiation block printed on 3D printer (Epel et al. [42])
Fig. 3. Diffusion fluorescence image of a live mouse with a transplanted tumor and adenoviral infection in the liver. Tumor cells express iRFP670 protein, liver cells express iRFP713 protein. The liver and the tumor are shown in green and red pseudocolors, respectively (Scherbakova, Verkhusha, [43])
