ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Contrast enhanced MRI of tumors using gadopentetic acid linked to cyclodextrin by an ester bond
About authors
1 Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
2 N. N. Blokhin Russian Cancer Research Center, Moscow, Russia
3 P. V. Sergeev Molecular Pharmacology and Radiobiology Department, Biomedical Faculty,
Pirogov Russian National Research Medical University, Moscow, Russia
4 Department of Petroleum Chemistry and Organic Catalysis, Faculty of Chemistry,
Lomonosov Moscow State University, Moscow, Russia
Correspondence should be addressed: Nikolay Shimanovsky
ul. Ostrovityanova, d. 1, Moscow, Russia, 117997; ur.umsr@namihs
About paper
Funding: this work was supported by Government Contract No. 11411.1008700.13.081 dated September 13, 2011 as part of the Federal Targeted Program for the Development of Pharmaceutical and Medical Industry of the Russian Federation until 2020.
Received: 2016-08-15
Accepted: 2016-08-25
Published online: 2017-01-05
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Fig. 1. MR images of mice with transplanted tumors (А — Са755, B — LLC and C — В16) before contrast administration
Fig. 2. MR images of mouse breast adenocarcinoma Ca755 5 minutes after injecting (А) Magnevist and (B) K14-1. The tumor area is circled
Fig. 3. MR images of mouse Lewis lung adenocarcinoma LLC 5 minutes after injecting (А) Magnevist and (B) K14-1. The tumor area is circled
Fig. 4. MR images of mouse melanoma B16 5 minutes after injecting (А) Magnevist and (B) K14-1. The tumor area is circled
Fig. 5. The curve shows dependency between signal-to-noise ratio in normal and tumor tissues and time elapsed after the injection of the studied contrast agents (A — Magnevist; B — K14-1) in mouse melanoma B16-F10
Table 2. Comparison of Magnevist and β-CD derivative (sample К14-1) effect on rat fibroblast viability
Note. # — data are presented as percentage from the control; the control is taken as 100 %.
