METHOD

Iodine quantification with computed tomography for the purpose of dose assessment in contrast enhanced radiotherapy

Lipengolts AA1,2,3, Budaeva JA2,3, Blaickner M4, Cherepanov AA1, Menkov MA1, Kulakov VN2, Grigorieva EYu1
About authors

1 N. N. Blokhin Russian Cancer Research Center, Moscow, Russia

2 A. I. Burnazyan Federal Medical and Biophysical Center, Moscow, Russia

3 National Research Nuclear University MEPhI, Moscow, Russia

4 Austrian Institute of Technology, Vienna, Austria

Correspondence should be addressed: Alexey A. Lipengolts
Kashirskoe shosse, d. 24, Moscow, Russia, 115478; ur.liam@stlognepil

Received: 2016-12-01 Accepted: 2016-12-06 Published online: 2017-01-19
|
  1. Norman A, Ingram M, Skillen RG, Freshwater DB, Iwamoto KS, Solberg T. X-ray phototherapy for canine brain masses. Radiat Oncol Investig. 1997; 5 (1): 8–14.
  2. Rose JH, Norman A, Ingram M, Aoki C, Solberg T, Mesa A. First radiotherapy of human metastatic brain tumors delivered by a computerized tomography scanner (CTRx). Int J Radiat Oncol Biol Phys. 1999; 45 (5): 1127–32.
  3. Hainfeld JF, Slatkin DN, Smilowitz HM. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol. 2004; 49 (4904): N309–15.
  4. Hainfeld JF, Smilowitz HM, O’Connor MJ, Dilmanian FA, Slatkin DN. Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Nanomedicine (Lond). 2013; 8 (10): 1601–9. DOI: 10.2217/nnm.12.165.
  5. Lipengolts AA, Cherepanov AA, Kulakov VN, Grigorieva EY, Sheino IN, Klimanov VA. Antitumor efficacy of extracellular complexes with gadolinium in Binary Radiotherapy. Appl Radiat Isot. 2015 Dec 1; 106: 233–6. DOI: 10.1016/j.apradiso.2015.07.051.
  6. Kulakov VN, Lipengolts AA, Grigorieva EYu, Shimanovskii NL. [Pharmaceuticals for Binary Radiotherapy and Their Use for the Treatment of Malignancies (A Review)]. Khimiko-Farmatsevticheskii Zhurnal. 2016; 50 (6): 19–25. Russian.
  7. Adam J, Vautrin M, Obeid L, Tessier A, Prezado Y, Renier M, et al. Contrast-enhanced Synchrotron Stereotactic Radiotherapy Clinical Trials from a Medical Physicist Point of View. Int J Radiat Oncol. 2014; 90 (1): S16–7.
  8. Solberg TD, Iwamoto KS, Norman A. Calculation of radiation dose enhancement factors for dose enhancement therapy of brain tumours. Phys Med Biol. 1992 Feb; 37 (2): 439–43.
  9. Cho SH. Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol. 2005; 50 (15): N163–73. DOI: 10.1088/0031-9155/50/15/N01.
  10. Roeske JC, Nunez L, Hoggarth M, Labay E, Weichselbaum RR.
  11. Verhaegen F, Reniers B, Deblois F, Devic S, Seuntjens J, Hristov D. Dosimetric and microdosimetric study of contrast- enhanced radiotherapy with kilovolt x-rays. Phys Med Biol. 2005; 50 (15): 3555–69. DOI: 10.1088/0031-9155/50/15/005.
  12. Robar JL, Riccio SA, Martin MA. Tumour dose enhancement using modified megavoltage photon beams and contrast media. Phys Med Biol. 2002; 47 (14): 2433–49.
  13. Hainfeld JF, O’Connor MJ, Dilmanian FA, Slatkin DN, Adams DJ, Smilowitz HM. Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions. Br J Radiol. 2011; 84 (1002): 526–33. DOI: 10.1259/bjr/42612922.
  14. Rousseau J, Boudou C, Estève F, Elleaume H. Convection- Enhanced Delivery of an Iodine Tracer Into Rat Brain for Synchrotron Stereotactic Radiotherapy. Int J Radiat Oncol Biol Phys. 2007; 68 (3): 943–51. DOI: 10.1016/j.ijrobp.2007.01.065.
  15. Le Duc G, Corde S, Charvet A-M, Elleaume H, Farion R, Le Bas J-F, et al. In Vivo Measurement of Gadolinium Concentration in a Rat Glioma Model by Monochromatic Quantitative Computed Tomography. Invest Radiol. 2004; 39 (7): 385–93.
  16. Cherepanov AA, Lipengolts AA, Vorobyeva ES, Kulakov VN, Klimanov VA, Grigorieva EYu. [Xperimental study of x-rays absorbed dose increase in medium containing high-Z element using fricke dosimeter]. Meditsinskaya fizika. 2016; 72 (4): 38–41. Russian.