ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
REVIEW
Long noncoding RNAs are a promising therapeutic target in various diseases
About authors
1 Laboratory of Functional Genomics,Research Centre of Medical Genetics, Moscow, Russia
2 Laboratory of Medical Genetic Technologies, Department of Basic Research of MDRI,Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
3 Genomic Functional Analysis Laboratory,Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia
Correspondence should be addressed: Alexandra Filatova
ul. Moskvorechie, d. 1, Moscow, Russia, 115478; ur.xednay@ccaam
About paper
Contribution of the authors to this work: Filatova AYu — planning, literature analysis, drafting of a manuscript; Sparber PA — literature analysis, drafting of a manuscript; Krivosheeva IA — literature analysis, drafting of a manuscript; Skoblov MYu — drafting of a manuscript. All authors participated in editing of the manuscript.
Received: 2017-06-25
Accepted: 2017-06-28
Published online: 2017-07-18
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The figure shows some of the gene therapy approaches targeting long noncoding RNA (lncRNA). (A) Transcription repression by CRISPRi. (B) RNA interference. (C) Antisense oligonucleotides (ASOs) activate RNAse H — dependent degradation of the RNA target by forming an RNA-DNA duplex. (D) ASOs block lncRNA binding to the repressive PRC2 complex
