2018 / 05

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DOI: 10.24075/brsmu.2018.066

ORIGINAL RESEARCH

Investigation of the level of DNA double-strand breaks and mechanisms of cell death under irradiation of lung cancer and melanoma cells with ultra-high dose rate photon radiation

Kulinich TM1, Krastelev EG2, Bykov YuA2, Smirnov VP2,3, Shishkin AM1, Ivanov AV1, Bozhenko VK1
About authors

1 Russian Scientific Center of Roentgenoradiology, Moscow

2 Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow

3 Research Institute of Technical Physics and Automation of Rosatom, Moscow

Correspondence should be addressed: Vladimir K. Bojenko
Profsoyuznaya 86, Moscow, 117997; ur.liam@oknejobv

About paper

Funding: this work was supported by the Russian Science Foundation (Project 15-10355).

Received: 2018-08-15 Accepted: 2018-11-28 Published online: 2018-12-09
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Fig. 1. Changes in the relative number of double-strand DNA breaks in А549 (A) and MelMtp-x (B) cells irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M)
Fig. 2. Changes in the number of killed cells in А549 (A) and MelMtp-x (B) cell cultures irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M)
Fig. 3. Changes in the proportion of apoptotic cells in А549 (A) and MelMtp-x (B) cell cultures irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M). Staining: annexin V — propidium iodide
Fig. 4. Changes in the proportion of necrotic cells in А549 (A) and MelMtp-x (B) cell cultures irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M). Staining: annexin V — propidium iodide