ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2018 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Investigation of the level of DNA double-strand breaks and mechanisms of cell death under irradiation of lung cancer and melanoma cells with ultra-high dose rate photon radiation
About authors
1 Russian Scientific Center of Roentgenoradiology, Moscow
2 Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow
3 Research Institute of Technical Physics and Automation of Rosatom, Moscow
Correspondence should be addressed: Vladimir K. Bojenko
Profsoyuznaya 86, Moscow, 117997; ur.liam@oknejobv
About paper
Funding: this work was supported by the Russian Science Foundation (Project 15-10355).
Received: 2018-08-15
Accepted: 2018-11-28
Published online: 2018-12-09
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Fig. 1. Changes in the relative number of double-strand DNA breaks in А549 (A) and MelMtp-x (B) cells irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M)
Fig. 2. Changes in the number of killed cells in А549 (A) and MelMtp-x (B) cell cultures irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M)
Fig. 3. Changes in the proportion of apoptotic cells in А549 (A) and MelMtp-x (B) cell cultures irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M). Staining: annexin V — propidium iodide
Fig. 4. Changes in the proportion of necrotic cells in А549 (A) and MelMtp-x (B) cell cultures irradiated with therapeutic (Rokus-AM) and ultrahigh dose rate photon radiation (Mir-M). Staining: annexin V — propidium iodide
