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DOI: 10.24075/brsmu.2018.066
Copyright: © 2018 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Investigation of the level of DNA double-strand breaks and mechanisms of cell death under irradiation of lung cancer and melanoma cells with ultra-high dose rate photon radiation

Kulinich TM1, Krastelev EG2, Bykov YuA2, Smirnov VP2,3, Shishkin AM1, Ivanov AV1, Bozhenko VK1
About authors

1 Russian Scientific Center of Roentgenoradiology, Moscow

2 Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow

3 Research Institute of Technical Physics and Automation of Rosatom, Moscow

Correspondence should be addressed: Vladimir K. Bojenko
Profsoyuznaya 86, Moscow, 117997; ur.liam@oknejobv

About paper

Funding: this work was supported by the Russian Science Foundation (Project 15-10355).

Received: 2018-08-15 Accepted: 2018-11-28 Published online: 2018-12-09
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  1. Habash M, Bohorquez LC, Kyriakou E, Kron T, Martin OA, Blyth BJ. Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer. Cancers (Basel). 2017; 9 (11): 147.
  2. Orth M, Lauber K, Niyazi M, Friedl AA, Li M, Belka C, et al. Current concepts in clinical radiation oncology. Radiat Environ Biophys. 2014; 53 (1): 1–29. PubMed PMID: 24141602.
  3. Ivanov SD, Stoljarova IV, Jamshanov VA, Minko BA, Belova VV, Vinokurov VL. Radiochuvstvitel'nost' DNK krovi kak predskazatel'nyj pokazatel' jeffektivnosti himioluchevoj terapii bol'nyh rakom shejki matki. Voprosy onkologii. 2016; 62 (4): 465–70.
  4. Konopacka M, Rogoliński J. Can high dose rates used in cancer radiotherapy change therapeutic effectiveness? Contemp Oncol (Pozn). 2016; 20 (1): 449–52.
  5. Slosarek K, Konopacka M, Rogolinski J, Sochanik A. Effect of dose-rate and irradiation geometry on the biological response of normal cells and cancer cells under radiotherapeutic conditions. Mutat Res Genet Toxicol Environ Mutagen. 2014; (773): 14–22.
  6. Wang Z, Zhao Z, Lu J, Chen Z, Mao A, Teng G, et al. A comparison of the biological effect of 125J seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells. PLoS One 2015; 10 (8): e0133728.
  7. Brehwens K, Bajinskis A, Haghdoost S, Wójcik A. Micronucleus frequencies and clonogenic cell survival in TK6 cells exposed to changing dose rates under controlled temperature conditions. Int J Radiat Biol. 2014; (90): 241–7.
  8. Grabovskij EV, Olejnik GM, Krastelev EG, Smirnov VP, Hmelevskij EV, Bozhenko VK, i dr. Analiz indukcii apoptoza limfocitov perifericheskoj krovi cheloveka sverhintensivnym gamma-izlucheniem in vitro. Vestnik RGMU. 2017; (6): 59–66.
  9. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009; 461 (7267): 1071–78. DOI: 10.1038/nature08467
  10. Belenko AA. Citogeneticheskie i fiziologicheskie jeffekty gamma-izluchenija i impul'sno-periodicheskogo rentgenovskogo izluchenija v somaticheskih kletkah cheloveka [dissertacija]. Tomsk, 2016.
  11. Zhukovec AG. Sovremennye principy i perspektivy lechenija melanomy kozhi. Onkologicheskij zhurnal. 2015; 9 (4): 69–76.
  12. Matchuk ON, Zamulaeva IA, Kovalev OA, Saenko AS. Mehanizmy radiorezistentnosti kletok SP kul'tury myshinoj melanomy V16. Citologija. 2013; 55 (8): 553–9.
  13. Tang L, Wei F, Wu Y, He Y, Shi L, Xiong F, et al. Role of metabolism in cancer cell radioresistance and radiosensitization methods. J Exp Clin Cancer Res. 2018; (37): 87.
  14. Den'gina N. V., Mitin T. Luchevaja terapija u bol'nyh s disseminirovannoj melanomoj: palliativ ili stremlenie k izlecheniju? Novosti onkologii. 2018 [19.02.2018]. Dostupno po ssylke: https://rosoncoweb.ru/news/oncology/2018/02/19-1/
  15. Durante M, Bräuer-Krisch E, Hill M. Faster and safer? FLASH ultra-high dose rate in radiotherapy. Br J Radiol. 2018; (91):1082.
  16. Durante M, Orecchia R, Loeffler JS. Charged-particle therapy in cancer: clinical uses and future perspectives. Nat Rev Clin Oncol. 2017 Aug; 14 (8): 483–95.