2018 / 05

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DOI: 10.24075/brsmu.2018.066
Copyright: © 2018 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Investigation of the level of DNA double-strand breaks and mechanisms of cell death under irradiation of lung cancer and melanoma cells with ultra-high dose rate photon radiation

Kulinich TM1, Krastelev EG2, Bykov YuA2, Smirnov VP2,3, Shishkin AM1, Ivanov AV1, Bozhenko VK1
About authors

1 Russian Scientific Center of Roentgenoradiology, Moscow

2 Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow

3 Research Institute of Technical Physics and Automation of Rosatom, Moscow

Correspondence should be addressed: Vladimir K. Bojenko
Profsoyuznaya 86, Moscow, 117997; ur.liam@oknejobv

About paper

Funding: this work was supported by the Russian Science Foundation (Project 15-10355).

Received: 2018-08-15 Accepted: 2018-11-28 Published online: 2018-12-09
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Research into the effects of radiation delivered at ultrahigh dose rates > 1 × 107 Gy/min to biological objects is a new promising area of radiobiology. The unique characteristics of the high-current nanosecond electron accelerator Mir-M enable its use in medical and biological research, specifically in the experiments aimed at investigating the effect of therapeutic doses at a dose rate up to 100 MGy/s. In this work we study the effects of ultrahigh dose rate photon radiation on human lung carcinoma (A549) and melanoma (MelMtp-x) cells lines and compare them with those of the therapeutic gamma unit Rokus-AM. We show that ultrahigh dose rates induce more significant damage in the studied cell lines at doses between 2 and 7 Gy, radioresistant melanoma being more sensitive to photon radiation delivered at ultrahigh dose rates.

Keywords: apoptosis, photon radiation, gamma radiation, X-rays, ultrahigh dose rate, DNA double strand breaks

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