ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Nanostructured photosensitizer based on a tetracationic derivative of bacteriochlorin for antibacterial photodynamic therapy
About authors
1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow
2 Department of laser micro-, nano- and biotechnologies, Institute of engineering physics for biomedicine, National Research Nuclear University "MEPHI", Moscow
3 Laboratory of gene engineering of pathogenic microorganisms, N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Moscow
4 Organic Intermediates and Dyes Institute, Moscow
Correspondеnce should be adressed: Gennady A. Meerovich
Vavilova, 38, Moscow, 119991;
Received: 2018-08-31
Accepted: 2018-09-27
Published online: 2018-12-31
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Fig. 1. Dependence of 4% Kolliphor ELP 3-Py4BСHp4Br4 dispersion absorption on its concentration
Fig. 2. Normalized fluorescence spectra of 3-Py4BСHp4Br4 dispersions, various concentrations (spectra 1, 2 — 0.005 mM; spectra 3, 4 — 0.05 mM) and lengths of cuvettes (spectra 1, 3 — 1 mm; spectra 2, 4 — 10 mm)
Fig. 3. Dependence of integral fluorescence intensity of 3-Py4BСHp4Br4 aqueous compositions on their molar concentration: 1 — in water; 2 — in blood plasma
Table. 3-Py4BСHp4Br4 MBC values, standard conditions (incubation time 0.5 h, exposure dose 20 J/cm2)
